FAM20C: A Potential Drug Target and Biomarker for Various Diseases

Target Name: FAM20C

NCBI ID: G56975

FAM20C

FAM20C: A Potential Drug Target and Biomarker for Various Diseases

The FAM20C gene is a non-coding RNA molecule that has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. FAM20C is a part of the FAM20 family of non-coding RNAs, which are known for their role in regulating gene expression and have been implicated in a wide range of cellular processes.

The FAM20C gene was first identified in 2012 using next-generation sequencing techniques. It is located on chromosome 6 and has a length of approximately 200 nucleotides. FAM20C is primarily expressed in the brain and is downregulated in various tissues, including the lungs, heart, and kidneys.

Several studies have suggested that FAM20C may be involved in a wide range of physiological processes, including cell survival, proliferation, and differentiation. It has been shown to be involved in the regulation of cell adhesion, cell signaling, and neurotransmitter release. FAM20C has also been implicated in the development and progression of various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia.

As a potential drug target, FAM20C has been studied for its potential therapeutic effects in a variety of diseases. Studies have shown that FAM20C may be a useful target for neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, as well as for cancer, autoimmune disorders, and other conditions that involve neuroinflammation.

One of the key advantages of FAM20C as a drug target is its high degree of expression in the brain, which makes it a potential candidate for therapeutic intervention. Additionally, its effects on neurotransmitter release and cell signaling pathways suggest that it may have a broad range of therapeutic applications.

In addition to its potential therapeutic uses, FAM20C has also been studied for its potential as a biomarker. Studies have shown that FAM20C levels are significantly decreased in various neurodegenerative diseases, including Alzheimer's disease, and that these changes in FAM20C levels may be an indicator of disease severity. Additionally, FAM20C has been shown to be a potential biomarker for cancer, and its levels have been found to be decreased in various types of cancer.

Overall, the FAM20C gene has a strong potential as a drug target and biomarker for a wide range of diseases. Further research is needed to fully understand its role in these conditions and to develop effective therapies based on its properties.

Protein Name: FAM20C Golgi Associated Secretory Pathway Kinase

Functions: Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth (PubMed:22582013, PubMed:23754375, PubMed:25789606). Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome (PubMed:26091039). Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity (PubMed:26091039). Phosphorylates ERO1A, enhancing its activity which is required to maintain endoplasmic reticulum redox homeostasis and for oxidative protein folding (PubMed:29858230, PubMed:34349020). During endoplasmic reticulum stress, phosphorylates P4HB/PDIA1 which induces a functional switch, causing P4HB to change from an oxidoreductase to a molecular chaperone (PubMed:32149426). This is critical to maintain ER proteostasis and reduce cell death under ER stress (PubMed:32149426). Phosphorylation of P4HB also promotes its interaction with ERN1, leading to reduced activity of ERN1, a key sensor for the endoplasmic reticulum unfolded protein response (PubMed:32149426). Required for osteoblast differentiation and mineralization (PubMed:34349020). Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1/OPN (PubMed:22582013, PubMed:25789606, PubMed:34349020). In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion (PubMed:26091039)

The "FAM20C Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about FAM20C comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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