LCAT: Key Enzyme in Cholesterol Biosyn (G3931)

Target Name: LCAT

NCBI ID: G3931

LCAT

LCAT: Key Enzyme in Cholesterol Biosyn

LCAT (Lecithin-cholesterol acyltransferase) is a protein that is expressed in various tissues throughout the body, including the liver, heart, and kidneys. It is a key enzyme in the cholesterol biosynthesis pathway and is involved in the conversion of low-density lipoprotein (LDL) cholesterol to high-density lipoprotein (HDL) cholesterol, which is considered a healthy cholesterol.

LDL cholesterol is a risk factor for the development of cardiovascular disease, including heart attack and stroke, due to its ability to promote the formation of plaque in the arteries. HDL cholesterol, on the other hand, is considered a protective factor and helps to lower the risk of cardiovascular disease by neutralizing LDL cholesterol.

LCAT is a protein that is expressed in various tissues throughout the body and is involved in the conversion of LDL cholesterol to HDL cholesterol. It is a key enzyme in the cholesterol biosynthesis pathway and is expressed in the liver, heart, and kidneys.

LCAT is a 12-kDa protein that is expressed in the liver, heart, and kidneys. It is a key enzyme in the cholesterol biosynthesis pathway and is involved in the conversion of LDL cholesterol to HDL cholesterol. It is expressed in various tissues throughout the body, including the liver, heart, and kidneys.

LCAT is a protein that is involved in the conversion of LDL cholesterol to HDL cholesterol, which is considered a healthy cholesterol. It is a key enzyme in the cholesterol biosynthesis pathway and is expressed in various tissues throughout the body, including the liver, heart, and kidneys.

LCAT is a protein that is expressed in various tissues throughout the body and is involved in the conversion of LDL cholesterol to HDL cholesterol, which is considered a protective factor in the development of cardiovascular disease. It is a key enzyme in the cholesterol biosynthesis pathway and is expressed in the liver, heart, and kidneys.

LCAT is a protein that is involved in the conversion of LDL cholesterol to HDL cholesterol, which is considered a healthy cholesterol. It is a key enzyme in the cholesterol biosynthesis pathway and is expressed in various tissues throughout the body, including the liver, heart, and kidneys.

LCAT is a protein that is expressed in various tissues throughout the body and is involved in the conversion of LDL cholesterol to HDL cholesterol, which is considered a protective factor in the development of cardiovascular disease. It is a key enzyme in the cholesterol biosynthesis pathway and is expressed in the liver, heart, and kidneys.

LCAT is a protein that is involved in the conversion of LDL cholesterol to HDL cholesterol, which is considered a healthy cholesterol. It is a key enzyme in the cholesterol biosynthesis pathway and is expressed in various tissues throughout the body, including the liver, heart, and kidneys.

LCAT is a protein that is expressed in various tissues throughout the body and is involved in the conversion of LDL cholesterol to HDL cholesterol, which is considered a protective factor in the development of cardiovascular disease. It is a key enzyme in the cholesterol biosynthesis pathway and is expressed in the liver, heart, and kidneys.

LCAT is a protein that is involved in the conversion of LDL cholesterol to HDL cholesterol, which is considered a healthy cholesterol. It is a key enzyme in the cholesterol biosynthesis pathway and is expressed in various tissues throughout the body, including the liver, heart, and kidneys.

LCAT is a protein that is expressed in various tissues throughout the body and is involved in the conversion of LDL cholesterol to HDL cholesterol, which is considered a protective factor in the development of cardiovascular disease. It is a key enzyme in the cholesterol biosynthesis pathway and is expressed in the liver, heart, and kidneys.

LCAT is a protein that is involved in the conversion of LDL cholesterol to HDL cholesterol, which is considered a healthy cholesterol. It is a key enzyme in the cholesterol biosynthesis pathway and is expressed in various tissues throughout the body, including the liver, heart, and kidneys.

LCAT is a protein that is expressed in various tissues throughout the body and is involved in the conversion of LDL cholesterol to HDL cholesterol, which is considered a protective factor in the development of cardiovascular disease. It is a key enzyme in the cholesterol biosynthesis pathway and is expressed in the liver, heart, and kidneys.

LCAT is a protein that is involved in the conversion of LDL cholesterol to HDL cholesterol, which is considered a healthy cholesterol. It is a key enzyme in the cholesterol biosynthesis pathway and is expressed in various tissues throughout the body, including the liver, heart, and kidneys.

LCAT is a protein that is expressed in various tissues throughout the body and is involved in the conversion of LDL cholesterol to HDL cholesterol, which is considered a protective factor in the development of cardiovascular disease. It is a key enzyme in the cholesterol biosynthesis pathway and is expressed in the liver, heart, and kidneys.

LCAT is a protein that is involved in the conversion of LDL cholesterol to HDL cholesterol, which is considered a healthy cholesterol. It is a key enzyme in the cholesterol biosynthesis pathway and is expressed in various tissues throughout the body, including the liver, heart, and kidneys.

LCAT is a protein that is expressed in various tissues throughout the body and is involved in the conversion of LDL cholesterol to HDL cholesterol, which is considered a protective factor in the development of cardiovascular disease. It is a key enzyme in the cholesterol biosynthesis pathway and is expressed in the liver, heart, and kidneys.

LCAT is a protein that is involved in the conversion of LDL cholesterol to HDL cholesterol, which is considered a healthy cholesterol. It is a key enzyme in the cholesterol biosynthesis pathway and is expressed in various tissues throughout the body, including the liver, heart, and kidneys.

LCAT is a protein that is expressed in various tissues throughout the body and is involved in the conversion of LDL cholesterol to HDL cholesterol, which is considered a protective factor in the development of cardiovascular disease. It is a key enzyme in the cholesterol biosynthesis pathway and is expressed in the liver, heart, and kidneys.

LCAT is a protein that is involved in the conversion of LDL cholesterol to HDL cholesterol, which is considered a healthy cholesterol. It is a key enzyme in the cholesterol biosynthesis pathway and is expressed in various tissues throughout the body, including the liver, heart, and kidneys.

LCAT is a protein that is expressed in various tissues throughout the body and is involved in the conversion of LDL cholesterol to HDL cholesterol, which is considered a protective factor in the development of cardiovascular disease. It is a key enzyme in the cholesterol biosynthesis pathway and is expressed in the liver, heart, and kidneys.

LCAT is a protein that is involved in the conversion of LDL cholesterol to HDL cholesterol, which is considered a healthy cholesterol. It is a key enzyme in the cholesterol biosynthesis pathway and is expressed in various tissues throughout the body, including the liver, heart, and kidneys.

LCAT is a protein that is expressed in various tissues throughout the body and is involved in the conversion of LDL cholesterol to HDL cholesterol, which is considered a protective factor in the development of cardiovascular disease. It is a key enzyme in the cholesterol biosynthesis pathway and is expressed in the liver, heart, and kidneys.

LCAT is a protein that is involved in the conversion of LDL cholesterol to HDL cholesterol, which is considered a healthy cholesterol. It is a key enzyme in the cholesterol biosynthesis pathway and is expressed in various tissues throughout the body, including the liver, heart, and kidneys.

LCAT is a protein that is expressed in various tissues throughout the body and is involved in the conversion of LDL cholesterol to HDL cholesterol, which is considered a protective factor in the development of cardiovascular disease. It is a key enzyme in the cholesterol biosynthesis pathway and is expressed in the liver, heart, and kidneys.

LCAT is a protein that is involved in the conversion of LDL cholesterol to HDL cholesterol, which is considered a healthy cholesterol. It is a key enzyme in the cholesterol biosynthesis pathway and is expressed in various tissues throughout the body, including the liver, heart, and kidneys.

LCAT is a protein that is expressed in various tissues throughout the body and is involved in the conversion of LDL cholesterol to HDL cholesterol, which is considered a protective factor in the development of cardiovascular disease. It is a key enzyme in the cholesterol biosynthesis pathway and is expressed in the liver, heart, and kidneys.

LCAT is a protein that is involved in the conversion of LDL cholesterol to HDL cholesterol, which is considered a healthy cholesterol. It is a key enzyme in the cholesterol biosynthesis pathway and is expressed in various tissues throughout the body, including the liver, heart, and kidneys.

LCAT is a protein that is expressed in various tissues throughout the body and is involved in the conversion of LDL cholesterol to HDL cholesterol, which is considered a protective factor in the development of cardiovascular disease. It is a key enzyme in the

Protein Name: Lecithin-cholesterol Acyltransferase

Functions: Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs) (PubMed:10329423, PubMed:19065001, PubMed:26195816). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107). Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (PubMed:10722751). Catalyzes the hydrolysis of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor or PAF) to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (PubMed:8016111). Also catalyzes the transfer of the acetate group from PAF to 1-hexadecanoyl-sn-glycero-3-phosphocholine forming lyso-PAF (PubMed:8016111). Catalyzes the esterification of (24S)-hydroxycholesterol (24(S)OH-C), also known as cerebrosterol to produce 24(S)OH-C monoesters (PubMed:24620755)

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