LETM1: A Transmembrane Protein Potential Drug Target Or Biomarker

Target Name: LETM1

NCBI ID: G3954

LETM1

LETM1: A Transmembrane Protein Potential Drug Target Or Biomarker

LETM1, or Leucine Zipper-EF-Hand Containing Transmembrane Protein 1, is a protein that has been identified as a potential drug target or biomarker. It is a transmembrane protein that is located in the endoplasmic reticulum (ER) and plays a role in the regulation of protein trafficking.

LETM1 was first identified in the late 1990s using a combination of biochemical, cellular, and genetic approaches. It is a 21-kDa protein that contains a unique arrangement of transmembrane domains. The protein has a long N-terminus that contains a leucine zipper, which is a type of transmembrane protein structure that is characterized by the presence of a long amino acid sequence that is zipped together in a specific order. The C-terminus of LETM1 contains a transmembrane domain that is composed of a catalytic site and a regulatory domain.

LETM1 is involved in the regulation of protein trafficking in the ER. The ER is a specialized organ that is responsible for the sorting and transport of proteins from the cytoplasm to the plasma membrane. The ER has a complex structure that is composed of a series of transmembrane domains that are responsible for different functions, such as the production of new proteins, the degradation of damaged proteins, and the regulation of protein trafficking.

LETM1 is one of the proteins that is involved in the regulation of protein trafficking in the ER. It is responsible for the localization of certain proteins to the ER and for the regulation of their trafficking to the plasma membrane. LETM1 is also involved in the regulation of the degradation of damaged proteins, which is an important function of the ER.

In recent years, there has been a growing interest in LETM1 as a potential drug target or biomarker. LETM1 has been shown to play a role in the regulation of a variety of cellular processes, including cell signaling, protein trafficking, and inflammation. It is also known to be involved in the regulation of the immune response and has been shown to play a role in the regulation of T cell development.

One of the potential reasons for the interest in LETM1 is its unique structure and its involvement in important cellular processes. LETM1 is a 21-kDa protein that contains a unique arrangement of transmembrane domains. This makes it an attractive target for drug developers because it is likely to be difficult to modify and because it is likely to have a stable structure that is resistant to changes in the cell.

Another reason for the interest in LETM1 is its involvement in the regulation of protein trafficking in the ER. As mentioned earlier, the ER has a complex structure and LETM1 is involved in the regulation of protein trafficking to the ER. This makes it an attractive target for drugs that are designed to modulate protein trafficking in the ER.

In addition, LETM1 is also involved in the regulation of the immune response and has been shown to play a role in the regulation of T cell development. This makes it an attractive target for drugs that are designed to modulate the immune response.

Overall, LETM1 is a protein that has been identified as a potential drug target or biomarker. Its unique structure and its involvement in important cellular processes make it an attractive target for drug developers. Further research is needed to fully understand the role of LETM1 in the regulation of protein trafficking and its potential as a drug target.

Protein Name: Leucine Zipper And EF-hand Containing Transmembrane Protein 1

Functions: Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport (PubMed:18628306, PubMed:19797662, PubMed:24898248, PubMed:24344246, PubMed:29123128, PubMed:32139798, PubMed:36321428, PubMed:36055214). Mediates proton-dependent calcium efflux from mitochondrion (PubMed:19797662, PubMed:24344246, PubMed:29123128). Functions also as an electroneutral mitochondrial proton/potassium exchanger (PubMed:24898248, PubMed:36055214, PubMed:36321428). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (PubMed:18628306, PubMed:36055214). Required for the maintenance of the tubular shape and cristae organization (PubMed:18628306, PubMed:32139798)

The "LETM1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LETM1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets