Leo1-like Protein Plays Role in Replicative Senescence and Aging

Target Name: LEO1

NCBI ID: G123169

LEO1

Other Name(s): Replicative senescence down-regulated leo1-like protein | LEO1 homolog, Paf1/RNA polymerase II complex component | RNA polymerase-associated protein LEO1 | LEO1_HUMAN | Leo1, Paf1/RNA polymerase II complex component, homolog | RNA polymerase-associated protein LEO1 (isoform 1) | LEO1 variant 1 | Leo1 Paf1/RNA polymerase II complex component | RDL | replicative senescence down-regulated leo1-like protein | LEO1 homolog, Paf1/RNA polymerase II complex component, transcript variant 1

Leo1-like Protein Plays Role in Replicative Senescence and Aging

LEO1 (Replicative senescence down-regulated leo1-like protein) is a protein that has been shown to play a role in the process of replicative senescence, which is the aging process that occurs in living organisms. The protein is also known as Leo1-like protein.

Replicative senescence is the process by which a cell replicates its DNA and proteins to prepare for cell division. As the cell replicates, it begins to prepare for the next cell division by producing a set of proteins that will be used for the cell division process. However, as the cell replicates, it also begins to break down and age. This process is known as senescence.

Leo1-like protein is a protein that is found in a variety of organisms, including bacteria, yeast, and animals. It is known to be involved in the process of replicative senescence.

One of the things that makes Leo1-like protein so interesting as a drug target is its role in the process of replicative senescence. As the cell replicates, it begins to break down and age. This process is closely linked to the aging process, and there is a lot of interest in finding drugs that can slow down or even reverse this process.

Leo1-like protein has been shown to play a role in the regulation of replicative senescence. It is known to be involved in the downregulation of Replicative Senescence-Regulated Proteins (RSPs), which are proteins that are involved in the replicative senescence process.

In addition, Leo1-like protein has also been shown to play a role in the regulation of cell cycle progression. It is known to be involved in the G1 phase of the cell cycle, which is the stage of cell growth and preparation for cell division.

Leo1-like protein is also interesting as a biomarker because it can be used to predict the aging process of an organism. By measuring the levels of Leo1-like protein in an organism, researchers can predict how long the organism is likely to live and even detect diseases that are associated with aging.

In conclusion, Leo1-like protein is a protein that has been shown to play a role in the process of replicative senescence. It is also known as Leo1-like protein and has been shown to be involved in the downregulation of Replicative Senescence-Regulated Proteins (RSPs) and the regulation of cell cycle progression. Leo1-like protein is also interesting as a drug target and can be used as a biomarker for predicting the aging process of an organism.

Protein Name: LEO1 Homolog, Paf1/RNA Polymerase II Complex Component

Functions: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling

The "LEO1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LEO1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets