LDAF1-2 Regulates Lipid Droplet Assembly and Function (G57146)

Target Name: LDAF1

NCBI ID: G57146

LDAF1

LDAF1-2 Regulates Lipid Droplet Assembly and Function

Lipid droplet assembly factor 1 (LDAF1) is a protein that plays a crucial role in the regulation of lipid metabolism. It is a member of the Lipid Droplet Assembly Factors (LDAF) family, which are known to interact with lipid droplets in various cell types. LDAF1 is expressed in various tissues and cells, including liver, muscle, and heart, and is involved in the formation and functions of lipid droplets.

The LDAF1 gene has four splice variants, which result in different isoforms of the protein. Transcript variant 2, also known as LDAF1-2, is the most abundant isoform. It is a 120 amino acid protein that has a calculated pI of 9.15. LDAF1-2 is predominantly expressed in the liver, where it is involved in the regulation of lipid metabolism.

LDAF1-2 functions as a protein that can interact with other proteins to regulate lipid droplet assembly and to control the size and composition of lipid droplets. It is part of the Lipid Droplet Signaling (LDS) pathway, which is a complex intracellular signaling pathway that regulates various cellular processes, including metabolism, inflammation, and autophagy.

The LDS pathway is a well-established signaling pathway that involves the formation of lipid droplets, which are small droplets of lipid molecules that are formed from the triglycerides of lipids. Lipid droplets are important for various cellular processes, including energy storage, signaling, and cell survival. They are also involved in the regulation of various cellular processes, including metabolism, inflammation, and autophagy.

LDAF1-2 is a key protein that regulates lipid droplet assembly and functions. It is involved in the formation of lipid droplets and in the regulation of their size and composition. It does this by interacting with other proteins that are involved in the LDS pathway.

One of the functions of LDAF1-2 is to regulate the size and composition of lipid droplets. Lipid droplets are formed from the triglycerides of lipids, which are derived from dietary lipids. These lipid droplets are involved in various cellular processes, including energy storage, signaling, and cell survival. They are also involved in the regulation of metabolism, inflammation, and autophagy.

LDAF1-2 is involved in the regulation of lipid droplets by interacting with various proteins that are involved in the LDS pathway. One of the well-known proteins that interacts with LDAF1-2 is lipid droplet-associated protein (LIPID), which is a protein that is involved in the formation and functions of lipid droplets.

LIPID is a 21 kDa protein that is expressed in various tissues and cells, including liver, muscle, and heart. It is involved in the formation and functions of lipid droplets and is regulated by various cellular processes, including metabolism, inflammation, and autophagy. LIPID is interacting with LDAF1-2 to regulate the size and composition of lipid droplets.

Another protein that interacts with LDAF1-2 is fatty acid-binding protein (FABP), which is a protein that is involved in the regulation of lipid metabolism. FABP is a 60 kDa protein that is expressed in various tissues and cells, including liver, muscle, and heart. It is involved in the formation and functions of lipid droplets and is regulated by various cellular processes, including metabolism, inflammation, and autophagy.

FABP is interacting with LDAF1-2 to regulate the size and composition of lipid droplets. It does this by interacting with the

Protein Name: Lipid Droplet Assembly Factor 1

Functions: Plays an important role in the formation of lipid droplets (LD) which are storage organelles at the center of lipid and energy homeostasis (PubMed:31708432). In association with BSCL2/seipin, defines the sites of LD formation in the endoplasmic reticulum (PubMed:31708432)

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