LEMD2: A Promising Protein for Drug Development (G221496)

Target Name: LEMD2

NCBI ID: G221496

LEMD2

LEMD2: A Promising Protein for Drug Development

LEMD2 (dJ482C21.1) is a protein that is expressed in various tissues of the body, including the brain, heart, liver, and muscle. It is a member of the leucine repeat-containing G protein-coupled receptor (GPCR) family, which is a large superfamily of GPCRs that play a critical role in cellular signaling.

LEMD2 is unique among GPCRs because of its unique gene structure and the specific way it is translated into a protein. Unlike most GPCRs, LEMD2 has a variable exon splicing pattern, which allows for multiple splice variants to be produced from a single gene. This gene structure makes LEMD2 a more versatile target for drug development because it allows for the production of different forms of the protein that may have different functions in different cell types.

LEMD2 is also a good candidate as a drug target because of its unique localization in the body. Unlike most GPCRs, which are found throughout the body, LEMD2 is primarily localized to the brain and nervous system. This localization makes it a more attractive target for drug development because it allows for the target to be more easily targeted to specific areas of the brain or nervous system that are affected by the disease.

In addition to its unique gene structure and localization, LEMD2 is also a promising biomarker for a variety of diseases. For example, LEMD2 has been shown to be highly expressed in the brains of individuals with Alzheimer's disease, which is a degenerative brain disorder that is characterized by the progressive loss of brain cells. This suggests that LEMD2 may be a useful biomarker for diagnosing or monitoring the progression of Alzheimer's disease.

Another application of LEMD2 as a drug target is its role in the regulation of pain. LEMD2 has been shown to play a role in the regulation of pain sensitivity, which makes it a potential target for pain medications. Additionally, LEMD2 has also been shown to play a role in the regulation of inflammation, which may make it a potential target for anti-inflammatory medications.

In conclusion, LEMD2 is a unique and promising protein that is worth further investigation as a drug target. Its unique gene structure and localization, as well as its potential as a biomarker for a variety of diseases, make it an attractive target for drug development. Further research is needed to fully understand the role of LEMD2 in cellular signaling and its potential as a drug target.

Protein Name: LEM Domain Nuclear Envelope Protein 2

Functions: Nuclear lamina-associated inner nuclear membrane protein that is involved in nuclear structure organization, maintenance of nuclear envelope (NE) integrity and NE reformation after mitosis (PubMed:16339967, PubMed:17097643, PubMed:28242692, PubMed:32494070). Plays a role as transmembrane adapter for the endosomal sorting complexes required for transport (ESCRT), and is thereby involved in ESCRT-mediated NE reformation (PubMed:28242692, PubMed:32494070). Promotes ESCRT-mediated NE closure by recruiting CHMP7 and downstream ESCRT-III proteins IST1/CHMP8 and CHMP2A to the reforming NE during anaphase (PubMed:28242692). During nuclear reassembly, condenses into a liquid-like coating around microtubule spindles and coassembles with CHMP7 to form a macromolecular O-ring seal at the confluence between membranes, chromatin, and the spindle to facilitate early nuclear sealing (PubMed:32494070). Plays a role in the organization of heterochromatin associated with the NE and in the maintenance of NE organization under mechanical stress (By similarity). Required for embryonic development and involved in regulation of several signaling pathways such as MAPK and AKT (By similarity). Required for myoblast differentiation involving regulation of ERK signaling (By similarity). Essential for cardiac homeostasis and proper heart function (By similarity)

The "LEMD2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LEMD2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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