NHLH2: Key Protein in Neuronal Circuit Development and Maintenance

Target Name: NHLH2

NCBI ID: G4808

NHLH2

NHLH2: Key Protein in Neuronal Circuit Development and Maintenance

NHLH2 (bHLHa34) is a protein that is expressed in various tissues of the human body, including the nervous system, and is involved in the development and maintenance of neuronal circuits. The protein is composed of four subunits, each of which has a distinct function in the neural circuitry.

One of the subunits of NHLH2 is the alpha subunit, which is responsible for the regulation of the activity of the other subunits. The alpha subunit is a transmembrane protein that is involved in the formation of chloride channels, which are essential for the proper functioning of the nervous system.

Another subunit of NHLH2 is the beta subunit, which is involved in the regulation of the activity of the alpha subunit. The beta subunit is also a transmembrane protein that is involved in the formation of chloride channels.

The gamma subunit of NHLH2 is responsible for the regulation of the activity of the alpha and beta subunits. The gamma subunit is also a transmembrane protein that is involved in the formation of chloride channels.

The delta subunit of NHLH2 is involved in the regulation of the activity of the alpha, beta, and gamma subunits. The delta subunit is also a transmembrane protein that is involved in the formation of chloride channels.

The epsilon subunit of NHLH2 is responsible for the regulation of the activity of the alpha, beta, gamma, and delta subunits. The epsilon subunit is also a transmembrane protein that is involved in the formation of chloride channels.

NHLH2 is a critical protein that is involved in the development and maintenance of neuronal circuits in the nervous system. The alpha, beta, gamma, and delta subunits of NHLH2 are involved in the regulation of the activity of chloride channels, which are essential for the proper functioning of the nervous system.

As a drug target or biomarker, NHLH2 may be useful in the treatment of various neurological disorders, including epilepsy, schizophrenia, and Alzheimer's disease. The regulation of chloride channels by NHLH2 is also a potential target for the development of new pharmaceuticals for the treatment of neurodegenerative diseases.

In conclusion, NHLH2 is a protein that is involved in the development and maintenance of neuronal circuits in the nervous system. The alpha, beta, gamma, and delta subunits of NHLH2 are involved in the regulation of the activity of chloride channels, which are essential for the proper functioning of the nervous system. As a drug target or biomarker, NHLH2 may be useful in the treatment of various neurological disorders, and its regulation of chloride channels may also be a potential target for the development of new pharmaceuticals for the treatment of neurodegenerative diseases.

Protein Name: Nescient Helix-loop-helix 2

Functions: Transcription factor which binds the E box motif 5'-CA[TC][AG]TG-3'. Involved in regulating energy expenditure, body mass, voluntary physical activity, mating behavior and reproductive longevity, acting through the hypothalamic-pituitary-gonadal axis. Acts as a transcriptional activator of target genes, including NDN, PCSK1, MC4R (By similarity). Is also a transcriptional activator of KISS1 (PubMed:35066646). May act centrally to regulate function of both white and brown adipose tissue. Together with NHLH1, required to maintain migration and survival of cells in the anterior extramural migration stream (aes), which forms the precerebellar nuclei. Also, in concert with NHLH1, may determine fate of gonadotropin releasing hormone-1 (GnRH-1) neurons

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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