NISCH: A Protein Regulator of The Immune System (G11188)

Target Name: NISCH

NCBI ID: G11188

NISCH

NISCH: A Protein Regulator of The Immune System

NISCH (NISCH_HUMAN) is a protein that is expressed in various tissues of the human body. It is a key regulator of the immune system and has been implicated in a number of diseases, including cancer. As a drug target or biomarker, NISCH is being targeted by researchers to develop new treatments for various diseases.

The NISCH protein is a key regulator of the immune system, and it is involved in the development and regulation of T cells, which are a critical part of the immune system. NISCH has been shown to play a role in the regulation of T cell development and function, and it has been implicated in a number of diseases, including cancer.

One of the key functions of NISCH is its role in the regulation of T cell receptor (TCR) signaling. TCR is a critical protein that is expressed in T cells and is involved in the recognition of foreign antigens by those cells. NISCH has been shown to play a key role in the regulation of TCR signaling by TCR-TCF, a protein that is critical for the development and function of T cells.

In addition to its role in TCR signaling, NISCH is also involved in the regulation of T cell responses to foreign antigens. NISCH has been shown to play a key role in the regulation of the activation and proliferation of T cells, as well as their differentiation into memory T cells.

NISCH has also been shown to play a role in the regulation of the production of antibodies, which are proteins that are critical for the immune response. NISCH has been shown to play a key role in the regulation of the production of antibodies by B cells, and its absence has been implicated in the development of autoimmune diseases.

In addition to its role in T cell and antibody regulation, NISCH has also been shown to play a role in the regulation of various other immune system functions, including the regulation of inflammation and the response to infection. NISCH has been shown to play a key role in the regulation of the production of cytokines, which are proteins that are critical for the immune response.

As a drug target or biomarker, NISCH is being targeted by researchers to develop new treatments for various diseases. For example, NISCH has been shown to be a potential drug target for the treatment of cancer, as its regulation of T cell and antibody production has been implicated in the development of cancer. NISCH has also been shown to be a potential biomarker for the diagnosis and prognosis of various diseases, including cancer.

In conclusion, NISCH is a protein that is expressed in various tissues of the human body and plays a critical role in the immune system. Its regulation of T cell and antibody production, as well as its involvement in the regulation of other immune system functions, makes it an attractive target for the development of new treatments for various diseases. As a drug target or biomarker, NISCH is being targeted by researchers to develop new treatments and biomarkers for a variety of diseases.

Protein Name: Nischarin

Functions: Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulated signal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation (By similarity). Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation (By similarity). Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells (By similarity). Inhibits lamellipodia formation, when overexpressed (By similarity). Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures

The "NISCH Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NISCH comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets