NLGN2: Key Regulator of Neural Development and Function (G57555)

Target Name: NLGN2

NCBI ID: G57555

NLGN2

NLGN2: Key Regulator of Neural Development and Function

NLGN2 (Neuroligin 2) is a gene that encodes for a protein known as NLGN2. The NLGN2 protein is a key regulator of neural development and function. It is expressed in many different tissues and cell types, including neurons, glial cells, and other neural cells. The NLGN2 protein plays a vital role in the development and maintenance of neural structure and function, and is often studied in the context of various neurological disorders.

One of the key functions of the NLGN2 protein is to regulate the production of extracellular vesicles (ECVs), which are small, fluid-like structures that are released from the surface of cells. ECVs are involved in many different cellular processes, including signaling, drug delivery, and cellular signaling. The NLGN2 protein helps to regulate the production of ECVs by controlling the activity of genes that are involved in ECV production.

Another important function of the NLGN2 protein is to regulate the formation of neural synapses, which are the connections between neurons. NLGN2 helps to regulate the production of the neurotransmitter acetylcholine, which is essential for the formation of new synapses. The NLGN2 protein also plays a role in the regulation of synaptic plasticity, which is the ability of the brain to change and adapt over time.

In addition to its role in neural development and function, the NLGN2 protein is also being studied as a potential drug target. There are many different approaches that researchers are using to target the NLGN2 protein, including inhibition of its activity using small molecules, genetic modification of neural cells to express the NLGN2 protein, and use of antibodies to block the NLGN2 protein. These approaches are being used to study the effects of the NLGN2 protein on neural development and function, as well as its potential as a drug target.

One of the most promising approaches to targeting the NLGN2 protein is the use of small molecules. Researchers have identified a number of compounds that have been shown to inhibit the activity of the NLGN2 protein. These compounds range from traditional medications that are already on the market, such as statins, to newly-discovered compounds that are being studied in the lab. Many of these compounds are being tested for their potential to treat a variety of neurological disorders, including Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders.

Another approach to targeting the NLGN2 protein is the use of genetic modification of neural cells. Researchers have used CRISPR-Cas9 technology to modify neural cells and introduce copies of the NLGN2 gene. This has allowed researchers to study the effects of the NLGN2 protein on neural development and function, as well as its potential as a drug target.

Finally, researchers have also been exploring the use of antibodies to block the NLGN2 protein. These antibodies are designed to specifically bind to the NLGN2 protein and prevent it from interacting with its receptors. By blocking the NLGN2 protein, researchers have been able to study its effects on neural development and function, as well as its potential as a drug target.

Overall, the NLGN2 protein is a key regulator of neural development and function. It plays a vital role in the production of extracellular vesicles, the formation of neural synapses, and the regulation of synaptic plasticity. As a result, the NLGN2 protein is an attractive target for researchers to study, and its potential as a drug target is being actively explored. By using a variety of approaches, including inhibition of its activity using small molecules, genetic modification of neural cells, and the use of antibodies, researchers are working to understand the full range of effects of the NLGN2 protein on neural development and function.

Protein Name: Neuroligin 2

Functions: Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4 (By similarity). Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity)

The "NLGN2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NLGN2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets