ANGPTL4: The Potential Drug Target and Biomarker (G51129)

Target Name: ANGPTL4

NCBI ID: G51129

ANGPTL4

ANGPTL4: The Potential Drug Target and Biomarker

Angiopoietin-like protein 4 (ANGPTL4) is a protein that has been identified as a potential drug target and biomarker for various diseases, including heart failure, cancer, and neurodegenerative disorders. Its unique structure and function have made it an attractive target for researchers to study, and recent studies have shed light on its potential as a drug.

ANGPTL4 is a 24-kDa transmembrane protein that is expressed in various tissues, including the heart, lungs, kidneys, and brain. It is characterized by a N-terminus that contains a unique domain called the N-terminal hypervariable region (N-HPVR), which is known for its ability to interact with various signaling molecules, including angiotensin II, a hormone that plays a critical role in blood pressure and cardiovascular function.

One of the key functions of ANGPTL4 is its ability to regulate the activity of angiotensin II. Angiotensin II is a potent stimulator of the production of matrix-derived growth factors (MDF), which are pro-inflammatory cytokines that play a key role in the development and progression of various diseases, including heart failure, cancer, and neurodegenerative disorders. By regulating the activity of angiotensin II, ANGPTL4 has been shown to have a positive impact on cardiovascular and neurodegenerative health.

In addition to its role in regulating angiotensin II, ANGPTL4 has also been shown to play a key role in the development and progression of various diseases. For example, ANGPTL4 has been shown to be overexpressed in various tissues and to contribute to the development of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. It has also been shown to be involved in the development of cancer, with studies suggesting that ANGPTL4 may be a potential biomarker for cancer progression.

Despite its potential as a drug target, ANGPTL4 has yet to be fully characterized, and much of its function and regulation remains unexplored. However, recent studies have shed light on its unique structure and function, as well as its potential as a drug target and biomarker.

One of the main challenges in studying ANGPTL4 is its complex structure and function. ANGPTL4 has a unique N-HPVR domain that is involved in its interaction with angiotensin II. This domain is known for its ability to interact with a variety of signaling molecules, including src/FAK, a protein that is involved in cell signaling and has been shown to be a potential drug target for various diseases.

In addition to its N-HPVR domain, ANGPTL4 has a number of other unique features that make it an attractive target for study. For example, it has a unique C-terminus that is involved in its interaction with the transcription factor NF-kappa-B. This interaction may have important implications for the regulation of ANGPTL4 function, and may be a potential target for drugs that are designed to modulate ANGPTL4 activity.

While ANGPTL4 is still an relatively new protein, it has already captured the attention of researchers due to its unique structure and function. Studies have shown that ANGPTL4 is involved in the regulation of angiotensin II, and that it has a positive impact on cardiovascular and neurodegenerative health. In addition, ANGPTL4 has also been shown to play a key role in the development and progression of various diseases, including cancer and neurodegenerative disorders.

Overall, ANGPTL4 is a protein that has captured the attention of researchers due to its unique structure and function. Its ability to regulate the activity of angiotensin II and its involvement in the development and progression of various diseases make it an attractive target for study, and

Protein Name: Angiopoietin Like 4

Functions: Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism (PubMed:19270337, PubMed:21398697, PubMed:27929370, PubMed:29899144). May also play a role in regulating glucose homeostasis and insulin sensitivity (Probable). Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (PubMed:14583458, PubMed:17068295). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro) (PubMed:17068295). Depending on context, may modulate tumor-related angiogenesis (By similarity)

The "ANGPTL4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ANGPTL4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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