Unlocking The Potential of Ubiquitin Fold Modifier 1 as A Drug Target Or Biomarker

Target Name: UFM1

NCBI ID: G51569

UFM1

Unlocking The Potential of Ubiquitin Fold Modifier 1 as A Drug Target Or Biomarker

Ubiquitin Fold Modifier 1 (UFM1) is a protein that plays a crucial role in the regulation of protein stability and degradation in the cell. UFM1 is a member of the ubiquitin family of proteins, which are involved in a wide range of cellular processes, including cell signaling, DNA repair, and inflammation. In recent years, researchers have increasingly recognized the potential of UFM1 as a drug target or biomarker for a variety of diseases.

The ubiquitin system is a complex protein-protein interaction network that plays a central role in ensuring the stability and integrity of damaged or dysfunctional proteins. UFM1 is one of the key components of this network, and it functions as a modifier of the ubiquitin protein. Specifically, UFM1 helps to link the ubiquitin protein to target proteins, which is essential for protein stability and degradation.

One of the key functions of UFM1 is its role in the regulation of protein stability. UFM1 can interact with various ubiquitin proteins and help to modulate their stability. This modulation is critical for the proper function of many cellular processes, including cell signaling, DNA repair, and inflammation. For example, UFM1 has been shown to play a role in the regulation of the stability of the protein p53, which is a well-known tumor suppressor protein.

In addition to its role in protein stability, UFM1 is also involved in the regulation of protein degradation. UFM1 can interact with the ubiquitin protein and help to modulate its stability. This modulation is critical for the proper function of many cellular processes, including cell signaling, DNA repair, and inflammation. For example, UFM1 has been shown to play a role in the regulation of the degradation of the protein p21, which is a well-known tumor suppressor protein.

UFM1 is also involved in the regulation of protein interactions. UFM1 can interact with various proteins and help to modulate their interactions. This modulation is critical for the proper function of many cellular processes, including cell signaling, DNA repair, and inflammation. For example, UFM1 has been shown to play a role in the regulation of the interaction between the protein T-cell factor (TCF) and its receptor, PDGFR-尾.

In conclusion, UFM1 is a protein that plays a crucial role in the regulation of protein stability, stability, and degradation in the cell. Its function as a modifier of the ubiquitin protein makes it an attractive drug target or biomarker for a variety of diseases. Further research is needed to fully understand the role of UFM1 in cellular processes and to develop effective treatments based on this protein.

Protein Name: Ubiquitin Fold Modifier 1

Functions: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer (PubMed:15071506, PubMed:20018847, PubMed:29868776, PubMed:27653677). The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1 (PubMed:15071506, PubMed:20018847, PubMed:29868776, PubMed:27653677). Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress (PubMed:32160526). Ufmylation of TRIP4 regulates nuclear receptors-mediated transcription (PubMed:25219498)

The "UFM1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about UFM1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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