UNC5C: A Potential Drug Target and Biomarker for Proteins Unrelated to Cancer

Target Name: UNC5C

NCBI ID: G8633

UNC5C

UNC5C: A Potential Drug Target and Biomarker for Proteins Unrelated to Cancer

Abstract:

Uncovering new potential drug targets and biomarkers is a crucial aspect of cancer research. UNC5C, or Protein unc-5 homolog 3, has been identified as a promising candidate for drug targeting and biomarker development due to its unique structure and function. This article will explore the potential of UNC5C as a drug target and biomarker for cancer.

Introduction:

Cancer is a leading cause of morbidity and mortality worldwide, with over 38 million new cases and 21 million deaths in 2020 alone. The development of new treatments and biomarkers is critical for improving cancer outcomes. One of the promising areas of research is the identification of novel protein targets for drug development and biomarker development. UNC5C, or Protein unc-5 homolog 3, is a protein that has been identified as a potential drug target and biomarker for cancer.

Structure and Function:

UNC5C is a 25 kDa protein that is expressed in a variety of tissues, including brain, heart, liver, and cervical cancer. It is characterized by a unique N-terminal domain that consists of a conserved alpha-helix and a variable region that includes a potential N-glycosylation site. The variable region of UNC5C contains a unique motif that is specific to the cell type and tissue of origin.

The UNC5C protein has been shown to play a role in several cellular processes, including cell adhesion, migration, and invasion. It has also been shown to be involved in the regulation of cell survival and apoptosis. In addition, UNC5C has been shown to be a potential drug target due to its unique structure and function.

Drug Target Potential:

UNC5C can be targeted by small molecules, antibodies, or peptides due to its unique structure and function. The N-terminal domain of UNC5C is conserved and can be targeted by small molecules or antibodies that bind to specific residues within this domain. The variable region of UNC5C is more flexible and can be targeted by peptides that contain specific residues within this region.

In addition to its potential as a drug target, UNC5C has also been shown to be a potential biomarker for cancer. The unique structure and function of UNC5C make it an attractive candidate for cancer diagnosis and monitoring. For example, UNC5C can be used as a biomarker to detect cancer in early stages, monitor disease progression, and evaluate the effectiveness of cancer treatments.

Biomarker Potential:

UNC5C has been shown to have potential as a biomarker for several types of cancer, including breast, ovarian, and cervical cancer. The unique structure and function of UNC5C make it an attractive candidate for cancer biomarker development.

In breast cancer, UNC5C has been shown to be expressed in the human breast tissue and has been shown to play a role in the development and progression of breast cancer. In ovarian cancer, UNC5C has been shown to be expressed in the human ovarian tissue and has been shown to play a role in the development and progression of ovarian cancer. In cervical cancer, UNC5C has been shown to be expressed in the human cervical tissue and has been shown to play a role in the development and progression of cervical cancer.

Conclusion:

UNC5C is a protein that has been identified as a potential drug target and biomarker for cancer. Its unique structure and function make it an attractive candidate for drug targeting and biomarker development. Further research is needed to fully understand the potential of UNC5C as a drug target and biomarker for cancer.

Protein Name: Unc-5 Netrin Receptor C

Functions: Receptor for netrin required for axon guidance (By similarity). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC (By similarity). Also involved in corticospinal tract axon guidance independently of DCC (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity)

The "UNC5C Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about UNC5C comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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