UNC-5CL: A Potential Drug Target and Biomarker (G222643)

Target Name: UNC5CL

NCBI ID: G222643

UNC5CL

UNC-5CL: A Potential Drug Target and Biomarker

Unc-5CL, also known as UNC-5CL1, is a non-coding RNA molecule that has been identified in various organisms, including humans. It is a member of the UNC family, which is characterized by the presence of a unique cytoplasmic domain in the N-terminus of the RNA molecule. The UNC family is involved in various cellular processes, including cell signaling, transcriptional regulation, and immune response.

UNC-5CL was first identified in the mouse genome using transcriptomics techniques. It is a small RNA molecule that has a length of approximately 240 nucleotides. UNC-5CL is highly conserved across various species, with similarities to UNC-5CL2 and UNC-5CL3 in mice, and UNC-5CL4 in humans.

Function and Interaction

UNC-5CL is involved in various cellular processes, including cell signaling, transcriptional regulation, and immune response. It is a key regulator of the cell cycle, and it is involved in the G1/S transition, G2/M transition, and G0/ G1 transition. UNC-5CL plays a role in the regulation of cell adhesion, and it is involved in the formation of tight junctions and adherens junctions in epithelial cells.

UNC-5CL is also involved in transcriptional regulation. It has been shown to play a role in the regulation of gene expression in various organisms, including mammals. For example, studies have shown that UNC-5CL can interact with the transcription factor, NF-kappa-B, to regulate the expression of target genes.

Drug Target and Biomarker

UNC-5CL is a potential drug target due to its involvement in various cellular processes that are targeted by small molecules. Several studies have shown that small molecules can interact with UNC-5CL and modulate its function. For example, studies have shown that inhibitors of the protein kinase, p38, can inhibit the activity of UNC-5CL and reduce the formation of mitochondrial stress granules.

In addition to its potential as a drug target, UNC-5CL is also a potential biomarker for various diseases. Its involvement in cell signaling and transcriptional regulation makes it a potential target for diseases associated with these processes, such as cancer, neurodegenerative diseases, and developmental disorders.

Conclusion

UNC-5CL is a non-coding RNA molecule that is involved in various cellular processes, including cell signaling, transcriptional regulation, and immune response. Its function and interaction with other molecules have been studied extensively, and it is a potential drug target and biomarker for various diseases. Further research is needed to fully understand the role of UNC-5CL in these processes and its potential as a drug.

Protein Name: Unc-5 Family C-terminal Like

Functions: Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets

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