UGT2B4: Key Enzyme in UDP-Glutamyl Transferase Family 2B4 (G7363)

Target Name: UGT2B4

NCBI ID: G7363

UGT2B4

UGT2B4: Key Enzyme in UDP-Glutamyl Transferase Family 2B4

UGT2B4 (hyodeoxycholic acid-specific UDP-glutamyl transferase 2B4) is a protein that is expressed in various tissues throughout the body. It is a key enzyme in theUDP-glutamyl transferase (UGT) family 2B4, which is involved in the metabolism of a variety of compounds, including drugs, toxins, and other substances that are harmful to the body. UGT2B4 is particularly interested in hyodeoxycholic acid, which is a natural compound that is found in many foods, such as fruits and vegetables, and that has been shown to have potential health benefits.

One of the main functions of UGT2B4 is to catalyze the transfer of a glutamyl group from UDP-glutamyl to a variety of different molecules. This transfer of the glutamyl group is a critical step in theUDP-glutamyl transferase reaction, which is the rate at which many harmful substances are metabolized and eliminated from the body. UGT2B4 is able to transfer the glutamyl group to a wide variety of different molecules, including toxins and other substances that are harmful to the body.

One of the ways that UGT2B4 is involved in the metabolism of hyodeoxycholic acid is by transferring the glutamyl group to the carbon atom of the hyodeoxycholic acid molecule. This transfer of the glutamyl group is important for the metabolism of hyodeoxycholic acid, as it allows it to be broken down into its constituent parts and excreted from the body.

UGT2B4 is also involved in the metabolism of other compounds that are important for the body, including drugs that are used to treat a variety of diseases. For example, some drugs that are used to treat cancer, such as taxanes and topiramate, are metabolized by UGT2B4 and other enzymes in the body. The activity of UGT2B4 can be inhibited by certain drugs, which can help to reduce the amount of these drugs that are metabolized and the amount of harm they cause to the body.

In addition to its role in the metabolism of hyodeoxycholic acid and other compounds, UGT2B4 is also involved in the regulation of other cellular processes in the body. For example, it is known to be involved in the signaling process that regulates cell growth and differentiation, and it is thought to play a role in the development and progression of certain diseases.

Overall, UGT2B4 is a protein that is involved in a variety of important cellular processes in the body. Its activity in theUDP-glutamyl transferase reaction is particularly important for the metabolism of hyodeoxycholic acid, and it is also involved in the regulation of other cellular processes. As a result, UGT2B4 is a potential drug target and a biomarker for a variety of diseases. Further research is needed to fully understand the role of UGT2B4 in the body and its potential as a therapeutic target.

Protein Name: UDP Glucuronosyltransferase Family 2 Member B4

Functions: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18719240, PubMed:23288867). Catalyzes the glucuronidation of the endogenous estrogen hormones such as estradiol and estriol (PubMed:18719240, PubMed:23288867)

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