Regulating Gene Expression and Cell Processes: LARP7's Role in Biology

Target Name: LARP7

NCBI ID: G51574

LARP7

Regulating Gene Expression and Cell Processes: LARP7's Role in Biology

La ribonucleoprotein 7 (LARP7) is a protein that plays a crucial role in regulating gene expression in various organisms, including humans. It is a transcriptional regulator, which means it helps to control the flow of genetic information from the DNA to the RNA that is used to create proteins. LARP7 is a key regulator of gene expression and has been identified as a potential drug target in the medical field.

LARP7 is a protein that is expressed in many different tissues and cells in the body. It is highly conserved across different species, which suggests that it has an important biological function. LARP7 is known to play a role in regulating gene expression by binding to specific DNA sequences and helping to control the access of RNA polymerase to these sequences. This allows LARP7 to regulate the translation of genetic information from DNA to RNA and ultimately protein.

LARP7 is a transcriptional regulator that is involved in the regulation of gene expression in various organisms, including humans. It is a key regulator of gene expression and has been identified as a potential drug target in the medical field.

One of the key functions of LARP7 is its role in regulating the production of proteins. LARP7 helps to control the translation of genetic information from DNA to RNA and ultimately protein. It does this by binding to specific DNA sequences and helping to prevent the access of RNA polymerase to these sequences. This allows LARP7 to regulate the production of proteins that are derived from DNA and to ensure that these proteins have the correct function.

Another important function of LARP7 is its role in regulating gene expression in response to various environmental conditions, such as changes in temperature, pH, and the availability of oxygen and nutrients. LARP7 is able to do this by binding to DNA sequences that are located close to the cytosol, which is the fluid that surrounds the cell. This allows LARP7 to regulate the expression of genes that are located in the cytosol, as well as those that are located in the cell nucleus.

LARP7 is also involved in the regulation of cell growth and division. It helps to control the production of RNA from the cell nucleus, which is used to create proteins that are needed for cell growth and division. LARP7 does this by binding to specific DNA sequences located in the nucleus and preventing the access of RNA polymerase to these sequences. This allows LARP7 to regulate the production of proteins that are needed for cell growth and division, and to ensure that these proteins are properly regulated.

In addition to its role in regulating gene expression, LARP7 is also involved in the regulation of cellular processes that are important for the survival of the cell. For example, LARP7 is involved in the regulation of the production of DNA, which is necessary for the cell to have a genetic template for the production of proteins. LARP7 also plays a role in the regulation of the transport of nutrients into the cell, which is necessary for the cell to have the energy and nutrients it needs to survive.

Overall, LARP7 is a protein that is involved in a wide range of cellular processes that are important for the survival and proper functioning of the cell. It is a potential drug target that could be developed as a new treatment for various diseases.

Protein Name: La Ribonucleoprotein 7, Transcriptional Regulator

Functions: RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function (PubMed:18249148, PubMed:32017898). Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II (PubMed:18249148, PubMed:18483487). The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:18249148, PubMed:18483487). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex (PubMed:18483487, PubMed:18281698). LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing (PubMed:32017898). Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes (PubMed:32017898). U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017898). Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif (PubMed:32017898). U6 snRNA processing is required for spermatogenesis (By similarity)

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