Understanding MYO6: The Myosin-VI Subfamily Protein (G4646)

Target Name: MYO6

NCBI ID: G4646

MYO6

Understanding MYO6: The Myosin-VI Subfamily Protein

Myosin-VI (MYO6), also known as Unconventional Myosin, is a protein that plays a critical role in muscle contractions. It is a member of the myosin family, which is known for their ability to generate force during muscle contraction. Despite its importance , MYO6 is not well understood, and there are limited research studies available on its biology.

The myosin family consists of several subfamilies, including the Myosin-I, Myosin-II, Myosin-III, and Myosin-IV subfamilies. These subfamilies have different properties and functions due to the presence or absence of different regulatory elements in their genes. MYO6 is a member of the Myosin-VI subfamily, which is characterized by the presence of a unique regulatory element called the N-terminal alpha-helices alpha-helical gene (N-HEAT).

MYO6 is a protein that is expressed in a variety of tissues, including muscle, heart, and brain. It is involved in the regulation of muscle contractions, and is thought to play a key role in the development and maintenance of muscle mass.

Despite its importance, there is limited research on MYO6. There are some studies that have investigated the biology of MYO6, but more research is needed to fully understand its role in muscle biology.

One potential drug target for MYO6 is the use of small molecules that can modulate the activity of MYO6. These small molecules can be used to treat muscle-related conditions, such as muscle weakness, muscle pain, and muscle disease.

Another potential biomarker for MYO6 is the use of gene expression arrays. By analyzing the expression patterns of MYO6 in muscle tissue, researchers can gain insights into the biology of this protein and identify potential targets for further investigation.

Conclusion

In conclusion, MYO6 is a protein that is critical to muscle biology. Despite its importance, there is limited research on its biology, and there is a need for further investigation to fully understand its role in muscle health and disease. The study of MYO6 may lead to new therapeutic approaches for treating muscle-related conditions and may provide valuable insights into the biology of muscle.

Protein Name: Myosin VI

Functions: Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (PubMed:10519557). Has slow rate of actin-activated ADP release due to weak ATP binding (By similarity). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway (PubMed:16507995). Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells (PubMed:11447109). Together with TOM1, mediates delivery of endocytic cargo to autophagosomes thereby promoting autophagosome maturation and driving fusion with lysosomes (PubMed:23023224). Links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN (PubMed:31371777). May act as a regulator of F-actin dynamics (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). May play a role in transporting DAB2 from the plasma membrane to specific cellular targets (By similarity). May play a role in the extension and network organization of neurites (By similarity). Required for structural integrity of inner ear hair cells (By similarity). Modulates RNA polymerase II-dependent transcription (PubMed:16949370)

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