YEATS2: A Potential Drug Target for Cancer, Neurodegenerative Diseases and Autoimmune Disorders

Target Name: YEATS2

NCBI ID: G55689

YEATS2

YEATS2: A Potential Drug Target for Cancer, Neurodegenerative Diseases and Autoimmune Disorders

YEATS2 (Yeast Extracellular Transmembrane Trafficking System 2) is a protein that is expressed in the yeast cell membrane and is involved in the transport of various molecules across the membrane. The YEATS2 protein has been identified as a potential drug target and a biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

The YEATS2 protein is composed of 16 predicted transmembrane domains and a cytoplasmic tail. It is involved in the transportation of a wide variety of molecules, including small molecules, ions, and proteins. The protein has been shown to play a role in the regulation of various cellular processes, including cell signaling, DNA replication, and metabolism.

One of the unique features of YEATS2 is its ability to transport proteins across the membrane in a process called anterior-to-posterior (ATP) transport. This type of transport is also known as symphonate transport and is a critical mechanism for the import of many different proteins into the cell. YEATS2 has been shown to play a role in the regulation of ATP transport and has been shown to interact with various protein partners, including the protein known as T-Scap.

In addition to its role in protein transport, YEATS2 has also been shown to play a role in the regulation of various cellular processes. For example, the protein has been shown to be involved in the regulation of cell signaling, including the regulation of the levels of the protein known as PDGF-D. Additionally, YEATS2 has been shown to be involved in the regulation of DNA replication, as well as the regulation of metabolism.

The potential drug target status of YEATS2 is due to its involvement in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Cancer is a disease that has a high mortality rate and is characterized by the formation of tumors. YEATS2 has been shown to play a role in the regulation of cell signaling, which is a critical mechanism for the development and progression of cancer. Additionally, the protein has also been shown to play a role in the regulation of DNA replication, which is also a critical mechanism for cancer development.

Neurodegenerative diseases are a group of diseases that are characterized by the progressive loss of brain cells. YEATS2 has been shown to play a role in the regulation of cell signaling and has been shown to interact with the protein known as N-cadherin. This interaction between YEATS2 and N-cadherin suggests that the protein may be involved in the regulation of the movement of cells along the neurons, which is a critical mechanism for the development and progression of neurodegenerative diseases.

Autoimmune disorders are a group of diseases in which the immune system targets the body's own tissues and causes inflammation and damage. YEATS2 has been shown to play a role in the regulation of cell signaling and has been shown to interact with the protein known as NF-kappa-B. This interaction between YEATS2 and NF-kappa-B suggests that the protein may be involved in the regulation of inflammation and immune responses.

In conclusion, YEATS2 is a protein that is expressed in the yeast cell membrane and is involved in the transport of various molecules across the membrane. The protein has been identified as a potential drug target and a biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Further research is needed to fully understand the role of YEATS2 in these diseases and to develop effective treatments.

Protein Name: YEATS Domain Containing 2

Functions: Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431)

The "YEATS2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about YEATS2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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