ZBED6: A Potential Drug Target and Biomarker (G100381270)

Target Name: ZBED6

NCBI ID: G100381270

ZBED6

Other Name(s): Zinc finger BED-type containing 6 | zinc finger BED-type containing 6 | Zinc finger BED domain-containing protein 6 | ZBED6_HUMAN | MGR

ZBED6: A Potential Drug Target and Biomarker

Zinc finger nucleosome (ZFN) domain-containing proteins play a crucial role in various cellular processes, including DNA replication, repair, and maintenance. One of the ZFN proteins that has garnered significant attention in recent years is ZBED6, which is characterized by the presence of a ZFN domain and a unique N-terminal region that consists of a long terminal repeat and a short cullin-like structure. ZBED6 has been shown to interact with various cellular components, including the histone histone-kimberling (HOK) complex, which is involved in the histamine response and inflammation.

The ZBED6 protein has been predicted to have several potential functions, including playing a role in the regulation of DNA replication, cell growth, and stress resistance. ZBED6 has also been shown to be involved in the regulation of the expression of target genes, which may be important for its functions in cellular processes.

In addition to its potential functions, ZBED6 has also been identified as a potential drug target. The ZBED6 gene has been shown to be highly conserved across various species, which suggests that it may be a promising target for small molecules. Furthermore, several studies have shown that inhibition of ZBED6 can lead to therapeutic effects, including inhibition of cancer cell growth and treatment of neurodegenerative diseases.

In terms of its potential as a biomarker, ZBED6 has been shown to be involved in the regulation of cellular processes, including cell growth, apoptosis, and inflammation. Therefore, it may be a useful biomarker for the diagnosis and prognosis of various diseases.

In conclusion, ZBED6 is a ZFN protein that has significant potential as a drug target and biomarker. Further research is needed to fully understand its functions and potential applications in cellular processes.

Protein Name: Zinc Finger BED-type Containing 6

Functions: Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3', transcription regulation may be tissue-specific (By similarity). Regulates the expression of target genes such as: IGF2, PGAP6/TMEM8, ENHO, and PIANP (By similarity). Acts as a transcriptional repressor of growth factor IGF2, thereby negatively regulating postnatal growth of muscles and internal organs, especially in females (By similarity). Negatively regulates myoblast differentiation and myoblast mitochondrial activity via its regulation of IGF2 transcription (By similarity). Negatively regulates the cell cycle of myoblasts, potentially via transcriptional regulation of the E2F family of transcription factors such as: E2F1 and E2F2 (By similarity). Positively regulates the cell cycle and survival of pancreatic beta cells (PubMed:24043816). Binds to the CDH2 gene and may directly repress CDH2 transcription (By similarity). Probably by controlling CDH2 expression, regulates pancreatic beta cell adhesion, and formation of cell-to-cell junctions between pancreatic beta cells and neural crest stem cells (By similarity). May also play a role in embryonic beta cell differentiation (By similarity). May play a role in insulin sensitivity and glucose clearance (By similarity)

The "ZBED6 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZBED6 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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