ZBTB40: A Potential Drug Target and Biomarker (G9923)

Target Name: ZBTB40

NCBI ID: G9923

ZBTB40

ZBTB40: A Potential Drug Target and Biomarker

Zinc finger and BTB domain-containing protein 40 (ISOform A), also known as ZBTB40, is a protein that plays a crucial role in various cellular processes. It is a key regulator of cell-cell adhesion, and its dysfunction has been implicated in various diseases, including cancer, neurodegenerative diseases, and developmental disorders. Therefore, targeting ZBTB40 has the potential to offer new therapeutic approaches for these diseases.

ZBTB40 is a 21-kDa protein that is expressed in various tissues, including brain, pancreas, and heart. It is composed of a N-terminal zinc finger domain, a B-type zinc-finger domain, and a C-terminal BTB domain. The N-terminal zinc finger domain is responsible for the regulation of protein stability and functions, while the B-type zinc-finger domain and C-terminal BTB domain are involved in protein-protein interactions and the regulation of cell-cell adhesion.

Studies have shown that ZBTB40 is involved in various cellular processes, including cell adhesion, migration, and invasion. It has been shown to regulate the formation and maintenance of tight junctions, which are essential for the separation of tissues and the regulation of ion and solute transport. ZBTB40 has also been shown to play a role in the regulation of cell-cell adhesion, which is critical for the development and maintenance of tissues and organs.

In addition to its role in cell-cell adhesion, ZBTB40 has also been shown to be involved in the regulation of various signaling pathways. For example, it has been shown to be involved in the regulation of the TGF-β pathway, which is a critical pathway involved in cell growth, differentiation, and cancer progression. ZBTB40 has also been shown to be involved in the regulation of the NF-kappa-B pathway, which is involved in inflammation and cellular signaling.

Given its involvement in various cellular processes, ZBTB40 has the potential to be a drug target or biomarker for various diseases. For example, ZBTB40 has been shown to be involved in the regulation of cell-cell adhesion, which could make it a potential target for diseases that are characterized by disrupted cell-cell adhesion, such as cancer. Additionally, ZBTB40's involvement in the regulation of signaling pathways could make it a potential target for diseases that are characterized by the misregulation of signaling pathways, such as neurodegenerative diseases.

In conclusion, ZBTB40 is a protein that plays a crucial role in various cellular processes, including cell adhesion and signaling pathways. Its dysfunction has been implicated in various diseases, including cancer and neurodegenerative diseases. Therefore, targeting ZBTB40 has the potential to offer new therapeutic approaches for these diseases. Further research is needed to fully understand the functions of ZBTB40 and its potential as a drug target or biomarker.

Protein Name: Zinc Finger And BTB Domain Containing 40

Functions: May be involved in transcriptional regulation

The "ZBTB40 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZBTB40 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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