Identification and Characterization of YWHAZ as A Potential Drug Target

Target Name: YWHAZ

NCBI ID: G7534

YWHAZ

Identification and Characterization of YWHAZ as A Potential Drug Target

YWHAZ (14-3-3-zeta) is a protein that is expressed in various tissues of the body, including the brain, pancreas, and heart. It is a member of the YWH complex, which is involved in the regulation of inflammation and stress responses. The identification and characterization of YWHAZ as a potential drug target or biomarker has significant implications for the development of new treatments for various diseases.

Expression and Localization

YWHAZ is a 21-kDa protein that is expressed in a variety of tissues, including the brain, pancreas, and heart. It is predominantly expressed in the brain, where it is found in the endoplasmic reticulum (ER) and in the cytoplasm. YWHAZ is also expressed in other tissues, including the pancreas, where it is found in the periphyletic region of the pancreas, and in the heart, where it is found in the cardiac muscle.

Function and Regulation

The function of YWHAZ is not well understood, but its role in the regulation of stress and inflammation responses is well established. YWHAZ is involved in the regulation of the expression of pro-inflammatory cytokines, such as TNF-alpha, IL-1, and IL-6. It does this by interacting with the nuclear factor kappa B (NFKB), which is a transcription factor that is involved in the regulation of inflammation and stress responses.

In addition to its role in the regulation of inflammation, YWHAZ is also involved in the regulation of cell survival and metabolism. It has been shown to play a role in the regulation of cell proliferation, apoptosis (programmed cell death), and autophagy (the breakdown of cells by macrophages).

Drug Targeting

The potential drug targeting of YWHAZ is based on its involvement in the regulation of inflammation and stress responses. YWHAZ has been shown to play a role in the regulation of TNF-alpha signaling, which is involved in the regulation of inflammation and stress responses.

One potential drug that may target YWHAZ is an inhibitor of the activity of the nuclear factor kappa B (NFKB), such as infliximab or adalimumab. These drugs work by inhibiting the activity of NFKB, which would reduce the production of pro-inflammatory cytokines and thereby reduce the level of inflammation.

Another potential drug that may target YWHAZ is a small molecule inhibitor of the activity of YWHAZ. For example, a recent study identified a small molecule compound that inhibited the activity of YWHAZ and reduced the production of pro-inflammatory cytokines.

Conclusion

The identification and characterization of YWHAZ as a potential drug target or biomarker has significant implications for the development of new treatments for various diseases. The regulation of inflammation and stress responses is a critical aspect of human health, and the regulation of YWHAZ by the nuclear factor kappa B (NFKB) is a key component of this regulation. The potential drug targeting of YWHAZ is based on its involvement in the regulation of inflammation and stress responses, and the development of new treatments for various diseases may be promising.

Protein Name: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase Activation Protein Zeta

Functions: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity)

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•   the target screening and validation;
•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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