Targeting DDX28: The Use of Small Molecules (G55794)

Target Name: DDX28

NCBI ID: G55794

DDX28

Targeting DDX28: The Use of Small Molecules

DDX28 (DEAE螖28) is a protein that is expressed in various tissues of the body, including the brain, heart, and gastrointestinal tract. It is a member of the dynein gene family, which encodes a protein involved in the transport of organelles in cells. The loss of function ofDDX28 has been implicated in a number of diseases, including neurodegenerative disorders, cancer, and cardiovascular disease.

The search for new drug targets and biomarkers has led to the identification ofDDX28 as a potential drug target. The use of small molecules and other compounds to modulate the activity ofDDX28 has been shown to be effective in animal models of several diseases.

Currently, several studies are being conducted to determine the efficacy and safety of different treatments that targetDDX28. These studies are providing valuable information about the potential clinical applications ofDDX28 as a drug target.

Targeting DDX28

One of the most effective ways to targetDDX28 is through the use of small molecules, such as drugs that can modulate the activity of the protein. These molecules can either bind toDDX28 and prevent it from interacting with its downstream targets, or they can alter the activity ofDDX28 in a way that reduces its function.

One class of small molecules that have been shown to be effective in modulatingDDX28 activity is called taxanes. Taxanes are a type of compound that is derived from the natural product pipelines of plants, such as daisy. They have been shown to be effective in treating a variety of cancers, including breast, ovarian, and prostate cancers.

In addition to taxanes, other small molecules, such as terapidine and camptothecin, have also been shown to be effective in modulatingDDX28 activity. These molecules work by binding to specific regions ofDDX28 and altering its structure and function.

Measuring DDX28 activity

To determine the effectiveness of different treatments in modulatingDDX28 activity, researchers have developed a variety of techniques that can measure the activity ofDDX28 in different contexts. These techniques include:

1. Immunofluorescence: This technique can be used to visualize the expression and distribution ofDDX28 in different tissues and cells. By using antibodies that bind toDDX28, researchers can determine the level ofDDX28 expression and identify areas of the body whereDDX28 is expressed.
2. Western blotting: This technique can be used to measure the concentration ofDDX28 in different tissues and cells. By using antibodies that bind toDDX28, researchers can determine the level ofDDX28 in the samples and compare it to a known value.
3. In vitro assays: In vitro assays can be used to measure the activity ofDDX28 in a controlled laboratory setting. For example, researchers can useDDX28 to transport organelles in cell culture and measure the movement of these organelles over time.
4. Knockdown/knockout: This technique can be used to reduce the level ofDDX28 in specific tissues or cells. By using RNA interference or CRISPR/Cas9 to knockdown the expression ofDDX28, researchers can determine its effect on the body.

The future ofDDX28 research

The identification ofDDX28 as a potential drug target has led to a great deal of interest in its study. Several studies have shown that the loss of function ofDDX28 is associated with a number of diseases, including neurodegenerative disorders, cancer, and cardiovascular disease.

In addition to its potential as a drug target,DDX28 is also being studied as a biomarker for several diseases. For example, researchers have shown that the level ofDDX28 is decreased in the brains of individuals with Alzheimer's disease, which suggests that it may be a useful biomarker for this disease.

Current

Protein Name: DEAD-box Helicase 28

Functions: Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function (PubMed:25683708, PubMed:25683715). May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity (PubMed:11350955)

The "DDX28 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DDX28 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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