DDX3Y: A Potential Drug Target and Biomarker for Fasting-Induced DNA Damage and Cellular Aging

Target Name: DDX3Y

NCBI ID: G8653

DDX3Y

DDX3Y: A Potential Drug Target and Biomarker for Fasting-Induced DNA Damage and Cellular Aging

Introduction

Several diseases are associated with the acceleration of cellular aging and age-related damage, including cancer, neurodegenerative diseases, and cardiovascular diseases. These conditions are often characterized by the accumulation of DNA damage, which can lead to the expression of genes involved in cell growth , repair, and stress response. The recent discovery of the double-stranded RNA-binding protein DDX3Y, an essential regulator of DNA double-strand break repair, has piqued interest in its potential as a drug target or biomarker for age-related diseases.

DDX3Y: A Nucleic Acid-Binding Protein

The protein DDX3Y, named after its creator, Dr. David D. Xu, is a non-coding RNA-binding protein that plays a crucial role in the regulation of DNA double-strand break repair. It is a member of the Xenoprotein (XP ) family, which includes several proteins involved in various cellular processes, including DNA repair, DNA replication, and protein-DNA interactions.

DDX3Y functions as an essential regulator of the DNA double-strand break repair pathway, which is a critical network that ensures the accurate repair of DNA double-strand breaks in damaged cells. DNA double-strand breaks are often generated by various factors, including ionizing radiation, endogenous double-strand break repair components, and errors during DNA replication. These breaks can lead to the accumulation of mutations, gene fusions, and other forms of genetic alterations, which can have a profound impact on cellular function and contribute to the development of age-related diseases.

DDX3Y is involved in the repair of both G- and T-strand DNA double-strand breaks. It can recognize and bind to specific DNA sequences that have been damaged by these types of breaks. Once bound, DDX3Y facilitates the formation of a double- strand repair complex, which includes several proteins involved in the repair process, such as the DNA-binding protein repair factor DNAI, and the polymerase DNA polymerase.

DDX3Y's Role in Aging and Cellular Damage

The accumulation of DNA damage and the aging process are closely intertwined. As cells age, they are exposed to various stressors, including radiation, oxidative stress, and inflammation. These stressors can cause DNA double-strand breaks, which can lead to the expression of genes involved in stress response, DNA repair, and cellular aging.

DDX3Y is well-established as a key regulator of DNA double-strand break repair in response to aging and stress. In a series of studies, researchers have shown that DDX3Y levels increase in human cells as they age, and that it plays a crucial role in the regulation of cellular aging and DNA damage.

In addition to its role in DNA repair, DDX3Y is also involved in the regulation of cellular stress responses. Double-strand DNA breaks can cause significant stress on the cellular system, leading to the expression of genes involved in stress response, such as the stress -responsive protein p53. However, the role of DDX3Y in regulating p53 activity is not well understood.

Potential Therapeutic Applications

The therapeutic potential applications of DDX3Y are vast, given its involvement in the regulation of DNA double-strand break repair and cellular aging. Here are some of the possible targets for future research:

1. Antioxidant therapy: As cells age, they become more susceptible to oxidative stress, which can contribute to the development of age-related diseases. DDX3Y is involved in the regulation of cellular stress responses, and thus, inhibiting its activity

Protein Name: DEAD-box Helicase 3 Y-linked

Functions: Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway (By similarity)

The "DDX3Y Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DDX3Y comprehensively, including but not limited to:
•   general information;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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