DEK: A Potential Drug Target for Various Diseases (G7913)

Target Name: DEK

NCBI ID: G7913

Content of Review Report on DEK Target / Biomarker

DEK

DEK: A Potential Drug Target for Various Diseases

The protein encoded by the gene DEK (DEK oncogene) is a key regulator of the DNA replication process in various organisms, including humans. The DEK gene has been implicated in the development and progression of numerous diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique mechanism of action and its involvement in various cellular processes have made it an attractive drug target for researchers to explore. In this article, we will provide an overview of DEK and its potential as a drug target.

Structure and Function

DEK is a member of the TATA-binding protein (TBP) family, which are known for their role in regulating gene expression and DNA replication. The TBP family consists of several subfamilies, including the DEK family, which is characterized by the presence of the amino acid Asp in the TP motif. DEK is a 21-kDa protein that contains 115 amino acid residues.

The DEK protein functions as a critical regulator of DNA replication in the eukaryotic nucleus. During DNA replication, the DEK protein plays a vital role in the initiation of the replication process by binding to the protamine N1-like protein (PML), which is located on the leading strand of DNA. PML functions as a molecular scaffold to ensure the proper alignment of the replication complex, while DEK ensures the initiation of DNA replication by binding to PML and facilitating the formation of the replication complex.

In addition to its role in DNA replication, DEK has also been shown to play a crucial role in the regulation of gene expression. DEK has been shown to interact with various transcription factors, including the factors responsible for regulating cell cycle progression, apoptosis, and inflammation. By interacting with these transcription factors, DEK can influence the expression of target genes and contribute to the regulation of cellular processes that are crucial for the maintenance of cellular homeostasis.

Drug Target Potential

The DEK protein has been identified as a potential drug target due to its involvement in various diseases. Its involvement in cancer, neurodegenerative diseases, and autoimmune disorders makes it an attractive target for small molecule inhibitors.

In the context of cancer, DEK has been shown to play a role in the regulation of cell cycle progression and the maintenance of chromosomal stability. Several studies have shown that DEK has been expressed and activated in various types of cancer, including breast, ovarian, and colorectal cancer. Additionally, DEK has been shown to play a role in the regulation of angiogenesis, which is the process by which new blood vessels are formed in tumors.

In neurodegenerative diseases, DEK has been implicated in the regulation of neurogenesis and the maintenance of neural stem cells. Several studies have shown that DEK is expressed in various neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. Additionally, DEK has been shown to play a role in the regulation of synaptic plasticity, which is the ability of the brain to change and adapt over time.

In autoimmune disorders, DEK has been implicated in the regulation of immune cell function and the regulation of inflammation. Several studies have shown that DEK is expressed in various autoimmune disorders, including rheumatoid arthritis, lupus, and multiple sclerosis. Additionally, DEK has been shown to play a role in the regulation of inflammation, which is a crucial aspect of autoimmune disorders.

In conclusion, DEK is a protein that has been shown to play a critical role in various cellular processes, including DNA replication, gene expression, and cell cycle progression. Its unique mechanism of action and its involvement in various diseases make it an attractive drug target for small molecule inhibitors. Further research is needed to fully understand the DEK protein and its potential as a drug target.

Protein Name: DEK Proto-oncogene

Functions: Involved in chromatin organization

The "DEK Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DEK comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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