DEFA8P: A Protein Involved in Pain and Inflammation Regulation

Target Name: DEFA8P

NCBI ID: G449491

DEFA8P

Other Name(s): DEFAP1 | Defensin alpha 8, pseudogene | defensin alpha 8, pseudogene

DEFA8P: A Protein Involved in Pain and Inflammation Regulation

DEFA8P (DEFAP1) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. Its full name is Defensin-like protein 8P, and it is a member of the Defensin family of proteins.

The Defensin family of proteins plays a crucial role in the immune system and the regulation of inflammation. They are involved in the recognition and response to foreign substances, as well as in the regulation of cellular signaling pathways.

DEFA8P is a 14-kDa protein that is expressed in the brain, heart, and kidneys. It is characterized by a calculated molecular weight of 19.9 kDa and a calculated pI of 1.5. It is found in the cytoplasm of cultured cells and in the extracellular matrix (ECM) of tissues.

One of the unique features of DEFA8P is its ability to interact with other proteins in the cell. It has been shown to interact with a variety of proteins, including the transcription factor NF-kappa-B and the cytokine TGF-β1. These interactions may play a role in the regulation of cellular processes such as cell growth, differentiation, and inflammation.

Another important function of DEFA8P is its role in the regulation of pain. It has been shown to play a negative role in the development of pain following injury (PFI), and to be involved in the regulation of pain sensitivity. This may be due to its ability to interact with opioid receptors, which are involved in the regulation of pain.

In addition to its role in pain regulation, DEFA8P is also involved in the regulation of inflammation. It has been shown to play a positive role in the regulation of inflammation in response to infection or inflammation, and to be involved in the recruitment of immune cells to the site of inflammation.

The potential drug target for DEFA8P is its role in pain regulation and its involvement in the regulation of inflammation.

In conclusion, DEFA8P is a protein that is expressed in various tissues of the body and is involved in the regulation of pain and inflammation. Its unique ability to interact with other proteins and its involvement in the regulation of pain and inflammation make it an attractive target for drug development. Further research is needed to fully understand the role of DEFA8P in cellular processes and its potential as a drug target.

Protein Name: Defensin Alpha 8, Pseudogene

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