DEFB135: A Potential Drug Target Or Biomarker (G613209)

Target Name: DEFB135

NCBI ID: G613209

DEFB135

DEFB135: A Potential Drug Target Or Biomarker

DEFB135 (DB135_HUMAN), a protein found in human placenta, has been identified as a potential drug target or biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique structure and expression pattern in different tissues make it an attractive target for drug development due to its potential to modulate various cellular processes, including cell proliferation, apoptosis, angiogenesis, and inflammation.

The protein encoded by DEFB135 is a member of the defensin family, which includes a variety of structurally similar proteins that play a critical role in the immune system. These proteins are involved in the regulation of cell survival, and their dysregulation has been implicated in the development of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the most significant features of DEFB135 is its expression pattern. It is highly expressed in various tissues, including the placenta, and its levels are often elevated in diseases associated with inflammation and oxidative stress, such as cancer, neurodegenerative diseases, and autoimmune disorders. This suggests that DEFB135 may be a useful biomarker for these diseases and may also be a potential drug target.

In addition to its expression pattern, DEFB135 has been shown to play a role in several cellular processes that are relevant to its potential as a drug target. For example, it has been shown to be involved in cell apoptosis, which is a critical process that helps regulate cell growth and survival. Its role in apoptosis may be related to its ability to induce cell death in response to various stimuli, including chemotherapy drugs and oxidative stress.

DEFB135 has also been shown to be involved in the regulation of cell proliferation, which is a critical process for the development and maintenance of tissues and organs. Its role in this process may be related to its ability to inhibit the growth-promoting effects of various signaling pathways, including the TGF-β pathway. This suggests that DEFB135 may be a useful target for drugs that are designed to inhibit cell proliferation and promote cell death.

Another potential mechanism by which DEFB135 may be involved in drug targeting is its role in the regulation of angiogenesis, which is the process by which new blood vessels are formed. Its involvement in this process may be related to its ability to regulate the production and distribution of new blood vessels, which is a critical step in the development of new tissues and organs. This suggests that DEFB135 may be a useful target for drugs that are designed to modulate angiogenesis and promote tissue growth.

In addition to its role in cell regulation, DEFB135 has also been shown to play a role in the immune system. Its expression is highly correlated with that of several immune cell populations, including natural killer cells, T cells, and B cells. This suggests that DEFB135 may be involved in the regulation of immune cell function and may be a potential target for drugs that are designed to modulate the immune system.

Given its unique structure and expression pattern, as well as its involvement in several cellular processes that are relevant to its potential as a drug target, DEFB135 is an attractive candidate for further investigation as a potential drug target or biomarker. Its potential applications in the development of new therapies for cancer, neurodegenerative diseases, and autoimmune disorders make it an important area of research.

Protein Name: Defensin Beta 135

Functions: Has antibacterial activity

The "DEFB135 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DEFB135 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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