Study of DDX6P1, A Potential Drug Target and Biomarker for Various Diseases

Target Name: DDX6P1

NCBI ID: G442192

DDX6P1

Other Name(s): DDX6-Lp | DEAD-box helicase 6 pseudogene 1 | DDX6P | bA150A6.3 | DEAD (Asp-Glu-Ala-Asp) box helicase 6 pseudogene 1

Study of DDX6P1, A Potential Drug Target and Biomarker for Various Diseases

DDX6P1 (DDX6-Lp), a protein that belongs to the dynein gene family, has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique structure and subcellular localization in the cell have made it an attractive target for small molecules and other therapeutic agents.

The dynein gene family is a group of genes that encode a protein involved in the proper functioning of mitochondria, which are energy-producing structures found in most eukaryotic cells. The protein encoded by the DDX6 gene is a 21-kDa protein that is predominantly localized to the mitochondria. It plays a critical role in regulating mitochondrial dynamics, including the movement of organelles and the formation of mitochondrial stress fibers.

DDX6P1 is a 194 amino acid protein that contains a unique 61 amino acid extension, known as the L-loop. This extension is involved in the formation of the protein-protein interaction network and has been implicated in various cellular processes, including cell signaling, DNA replication, and stress response.

In addition to its role in cellular signaling, DDX6P1 has also been shown to play a key role in the development and progression of various diseases. For example, it has been shown to be overexpressed in various types of cancer, including breast, ovarian, and colorectal cancers. Additionally, it has been implicated in the development of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

The subcellular localization of DDX6P1 in the cell also makes it an attractive target for small molecules and other therapeutic agents. Because it is primarily localized to the mitochondria, small molecules that can specifically target the mitochondria and modulate cellular processes, such as energy metabolism and stress response, may be effective in treating diseases caused by dysfunction in these processes.

One of the challenges in studying the potential drug target and biomarker properties of DDX6P1 is its complex cellular localization and the need for specific tools to study its function. To overcome this challenge, researchers have developed various techniques to study its localization and function, including immunofluorescence, biochemical assays, and in vitro cell assays.

Immunofluorescence is a widely used technique to study the localization of proteins in the cell. By using antibodies that recognize specific amino acid residues within the protein, researchers can visualize the protein in specific cells and tissues and determine its localization in response to various conditions. This technique has been used to study the localization of DDX6P1 in various types of cancer and neurodegenerative diseases.

In addition to immunofluorescence, biochemical assays have also been used to study the function of DDX6P1. For example, researchers have used biochemical assays to measure the levels of DDX6P1 in the cell and to study its effects on various cellular processes, including cell signaling, DNA replication, and stress response. These assays have provided valuable information about the molecular mechanisms underlying the function of DDX6P1 and have identified potential targets for small molecules and other therapeutic agents.

In vitro cell assays have also been used to study the function of DDX6P1. These assays involve culturing cells in vitro and exposing them to various conditions, such as small molecules or other therapeutic agents, in order to determine the effects of these conditions on the cellular processes and functions of the cells. In vitro cell assays have been used to study the effects of various small molecules on the localization and function of DDX6P1, as well as to identify potential biomarkers for

Protein Name: DEAD-box Helicase 6 Pseudogene 1

The "DDX6P1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DDX6P1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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