Target Name: FAM66B
NCBI ID: G100128890
Review Report on FAM66B Target / Biomarker Content of Review Report on FAM66B Target / Biomarker
Other Name(s): family with sequence similarity 66 member B | Family with sequence similarity 66, member E | Family with sequence similarity 66 member B | FAM66E

Introduction to FAM66B

FAM66B (Family With Sequence Similarity 66 Member B) is a protein-coding gene located on chromosome 16q24.3. This gene produces the FAM66B protein, which is highly conserved among mammals and may play a significant role in various disease processes. In recent years, FAM66B has emerged as a potential drug target and biomarker for several diseases due to its involvement in key cellular processes. This article will delve into the functions of FAM66B and explore its potential as a drug target or biomarker.

The Role of FAM66B in Cellular Processes

FAM66B is known to be involved in a variety of cellular processes, including cell proliferation, apoptosis, and DNA damage response. Research suggests that FAM66B may act as a transcriptional regulator, modulating the expression of genes involved in these critical cellular processes.

One study found that FAM66B interacts with the retinoblastoma (RB) protein, a tumor suppressor that regulates cell cycle progression. This interaction suggests that FAM66B may be involved in controlling cell proliferation and potentially contribute to the development of cancer. Additionally, FAM66B has been shown to play a role in regulating the DNA damage response, suggesting its importance in maintaining genomic stability.

FAM66B as a Drug Target

The essential role of FAM66B in regulating critical cellular processes makes it an attractive target for drug development. By modulating the expression or function of FAM66B, it may be possible to manipulate the cell cycle, inhibit cell proliferation, or enhance the DNA damage response.

One potential therapeutic approach could involve developing small molecules that specifically interact with FAM66B and disrupt its activity. By targeting the FAM66B-RB interaction, it may be possible to inhibit cell proliferation and potentially halt the growth of cancerous cells. Additionally, drugs that enhance FAM66B expression or activity may boost the DNA damage response, making them useful in battling diseases characterized by DNA damage, such as neurodegenerative disorders.

However, the development of drugs targeting FAM66B is still in its early stages. Further research is needed to fully understand the structure and function of FAM66B and to identify specific binding sites that can be targeted by drug molecules. Additionally, preclinical and clinical studies to evaluate the safety and efficacy of these potential drugs will be necessary.

FAM66B as a Biomarker

In addition to its potential as a drug target, FAM66B may serve as a valuable biomarker for several diseases. Biomarkers are measurable indicators that can provide information about the presence, severity, or progression of a disease. In the case of FAM66B, its altered expression levels in certain diseases make it a promising biomarker candidate.

Studies have found dysregulation of FAM66B expression in various cancers, including breast, lung, and gastric cancer. Increased FAM66B expression has been associated with poor prognosis and aggressive tumor behavior. By measuring FAM66B levels in patient samples, clinicians may gain valuable insights into disease progression and tailor treatment strategies accordingly.

Furthermore, FAM66B has shown potential as a biomarker for neurodegenerative disorders. Research suggests that alterations in FAM66B expression may be implicated in the development of diseases such as Alzheimer's and Parkinson's, which are characterized by DNA damage and impaired DNA repair mechanisms. Monitoring FAM66B levels in patient samples may help identify individuals at risk or track disease progression.


FAM66B is a protein-coding gene that plays a critical role in various cellular processes, including cell proliferation, apoptosis, and DNA damage response. Its involvement in these processes positions FAM66B as a potential drug target and biomarker for several diseases.

While the development of drugs targeting FAM66B is still in its early stages, it holds great promise in the fields of oncology and neurodegenerative disorders. Furthermore, the potential use of FAM66B as a biomarker may facilitate early disease detection and help guide treatment decisions.

Continued research into the functions and mechanisms of FAM66B is essential for fully understanding its potential as a drug target or biomarker. Further studies exploring the efficacy and safety of potential drugs targeting FAM66B, as well as large-scale clinical trials assessing its biomarker potential, will be critical in realizing its clinical applications.

Protein Name: Family With Sequence Similarity 66 Member B

The "FAM66B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about FAM66B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at

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FAM66D | FAM66E | FAM76A | FAM83A-AS1 | FAM83E | FAM83H antisense RNA 1 (head to head) | FAM86B2-DT | FAM86JP | FAM86KP | FAM90A26 | FAM95B1 | FAM95C | FAM99B | FAM9A | FAM9B | FAM9C | FAR2P2 | FARP1 | FARSB | FAS-AS1 | FAT3 | FBLIM1 | FBXL12 | FBXL19 | FBXO39 | FBXO42 | FBXW5 | FCF1P11 | FCF1P2 | FCGR1CP | FCSK | FDPSP6 | FEM1B | FEV | FGD5-AS1 | FGD5P1 | FGF12-AS2 | FGF13-AS1 | FGF14-AS1 | FGFR3P1 | FGFRL1 | FILNC1 | FITM1 | FKBP1A-SDCBP2 | FKSG29 | FLJ16779 | FMC1-LUC7L2 | FMR1-AS1 | FN1 | FNBP1P1 | FNDC7 | FNDC8 | FOXD3-AS1 | FOXL3-OT1 | FOXO3 | FOXO6 | FOXP4-AS1 | FPGT-TNNI3K | FRA10AC1 | FRAT1 | FREM3 | FRG1HP | FRG2C | FRMD6-AS2 | FRY | FRY-AS1 | FSBP | FSCN3 | FSIP1 | FTH1P22 | FTH1P24 | FTHL17 | FTLP16 | FTO-IT1 | FTOP1 | FTSJ3 | FTX | FUT11 | FXYD1 | FXYD3 | FXYD4 | FXYD5 | FXYD6 | FXYD6-FXYD2 | FXYD7 | FYB2 | FZD4-DT | G3BP1 | GABPB1-AS1 | GACAT2 | GADD45A | GAGE12D | GAGE12F | GAGE8 | GALNT13-AS1 | GALNT15 | GALNT9-AS1 | GALNTL5 | GAPDHP14 | GAPDHP42