FAM27B: A Drug Target / Disease Biomarker (G100133121)

Target Name: FAM27B

NCBI ID: G100133121

FAM27B

Other Name(s): FAM27A2 | Family with sequence similarity 27 member B | BA12A20.3 | family with sequence similarity 27 member B

FAM27B: A Drug Target / Disease Biomarker

Fam27B, also known as FAM27B-AS-217, is a protein that is expressed in various tissues of the body, including the brain, heart, and gastrointestinal tract. It is a member of the FAM27 family of proteins, which are known for their role in cell signaling and inflammation. In recent years, research has suggested that Fam27B may be a drug target or biomarker, with potential applications in a variety of therapeutic areas.

The FAM27 family of proteins was identified through studies of gene expression and DNA-protein interactions. The FAM27 family consists of at least six proteins, including Fam27A, Fam27B, Fam27C, Fam27D, Fam27E, and Fam27F. These proteins share a conserved catalytic core and a variety of non-conserved domains, including a N-terminal transmembrane region, a coiled-coil domain, and a C-terminal TIRAS-like domain.

Fam27B is a 21 kDa protein that is expressed in various tissues of the body, including the brain, heart, and gastrointestinal tract. It is highly conserved in its structure, with a similar amino acid sequence to the other members of the FAM27 family. Fam27B has been shown to play a role in cell signaling and inflammation.

One potential function of Fam27B is as a drug target. Activation of Fam27B has been shown to induce various cellular signaling pathways, including the production of reactive oxygen species (ROS) and the activation of caspases. These signaling pathways are involved in a variety of cellular processes, including cell death, apoptosis, and inflammation. As a result, Fam27B has been shown to be a potential drug target for a variety of therapeutic diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

In addition to its potential as a drug target, Fam27B has also been suggested as a biomarker for certain diseases. For example, Fam27B has been shown to be expressed in the brains of individuals with Alzheimer's disease, and its levels have been associated with the severity of the disease. Similarly, Fam27B has been shown to be expressed in the blood of individuals with Parkinson's disease, and its levels have been associated with the severity of the disease. These findings suggest that Fam27B may be a useful biomarker for the diagnosis and progression of certain neurodegenerative diseases.

Fam27B has also been shown to play a role in cell signaling and inflammation in the normal development and function of various tissues. For example, Fam27B has been shown to be involved in the regulation of cell proliferation and differentiation in the intestine, and its levels have been shown to be affected by various environmental and genetic factors. Similarly, Fam27B has been shown to be involved in the regulation of inflammation in the brain, and its levels have been shown to be affected by various inflammatory cytokines.

In conclusion, Fam27B is a protein that is expressed in various tissues of the body and has been shown to play a role in cell signaling and inflammation. Its potential as a drug target and biomarker make it an attractive target for further research and development in a variety of therapeutic areas. Further studies are needed to fully understand the functions of Fam27B and its potential as a therapeutic agent.

Protein Name: Family With Sequence Similarity 27 Member B

The "FAM27B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about FAM27B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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