CysLTR2: A Potential Drug Target and Biomarker (G57105)

Target Name: CYSLTR2

NCBI ID: G57105

CYSLTR2

CysLTR2: A Potential Drug Target and Biomarker

Cysteinyl leukotriene receptor 2 (CysLTR2) is a G protein-coupled receptor (GPCR) that plays a crucial role in regulation of allergic responses and airway inflammation. It is expressed in various tissues, including airways, blood vessels, and epithelial cells, and is involved in the regulation of allergic reactions, such as itching, congestion, and inflammation. CysLTR2 has also been implicated in asthma, allergies, and Chronic obstructive pulmonary disease (COPD). Therefore, targeting CysLTR2 could be a promising strategy for the development of new treatments for these diseases.

CysLTR2 is a 12-kDa transmembrane protein that consists of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain is composed of a N-terminal alpha-helix and a C-terminal proline-rich region, which is involved in protein-protein interactions and cell adhesion. The transmembrane domain is composed of a single transmembrane alpha-helix and is responsible for the regulation of cell signaling pathways. The intracellular domain is composed of a single alpha-helix and is involved in protein-protein interactions and signaling pathways.

CysLTR2 is involved in the regulation of cellular processes that are critical for the development and maintenance of the immune response, such as T cell development, B cell activation, and inflammation. It has been shown that CysLTR2 is involved in the regulation of T cell responses , including cell subset, costimulation, and survival. CysLTR2 has also been shown to be involved in the regulation of B cell responses, including clonal expansion, antibody production, and memory.

In addition to its role in cellular processes, CysLTR2 has also been shown to play a role in the regulation of allergic responses and airway inflammation. Studies have shown that CysLTR2 is involved in the regulation of histamine responses, including release from mast cells and basophiles, and modulation of inflammatory cytokines, such as TNF-alpha, IL-4, and IL-5. CysLTR2 has also been shown to be involved in the regulation of allergen responses, including the regulation of IgE and IgG responses.

CysLTR2 has also been shown to be involved in the regulation of angiogenesis, which is the process by which new blood vessels are formed. Studies have shown that CysLTR2 is involved in the regulation of angiogenesis in various organisms, including the regulation of blood vessel diameter, cell proliferation, and vascular remodeling.

Given the importance of CysLTR2 in cellular processes and its involvement in the regulation of allergic responses and airway inflammation, targeting CysLTR2 could be a promising strategy for the development of new treatments for these diseases. Several potential drug targets have been identified for CysLTR2, including inhibition of the interaction between CysLTR2 and ligand, modulation of the cytoskeleton, and modulation of the intracellular signaling pathways that are involved in the regulation of CysLTR2.

In addition to its potential as a drug target, CysLTR2 has also been identified as a potential biomarker for various respiratory diseases, including asthma, allergies, and COPD. The cytoskeleton is a complex structure that is involved in the regulation of cellular processes, including cell signaling pathways. The cytoskeleton is composed of several components, including microtubules, actin filaments, and intermediate filaments.

Protein Name: Cysteinyl Leukotriene Receptor 2

Functions: Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4

The "CYSLTR2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CYSLTR2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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