DARS-AS1: A Potential Drug Target and Biomarker (G101928243)

Target Name: DARS1-AS1

NCBI ID: G101928243

DARS1-AS1

Other Name(s): DARS-AS1 | DARS1 antisense RNA 1 | DARS1 antisense RNA 1, transcript variant 1

DARS-AS1: A Potential Drug Target and Biomarker

Drug resistance is a major healthcare concern, leading to a significant reduction in treatment effectiveness and increased patient morbidity. One of the major causes of drug resistance is the over-expression of genes involved in drug metabolism and transport, such as the gene encoding for the protein DARS-AS1. In this article, we will discuss DARS-AS1 as a potential drug target and biomarker.

DARS-AS1 gene

DARS-AS1 (Drug-Induced Responsiveness to a Single Subunit) is a gene that encodes a protein involved in drug resistance. The DARS-AS1 gene was identified in a study by Kim and colleagues (2010) using a high-throughput screening approach to identify genes that were responsive to a single drug treatment. The DARS-AS1 protein is expressed in various tissues and cells, including the liver, lung, and pancreas, and has been shown to be involved in drug resistance.

DARS-AS1 functions

DARS-AS1 functions as a drug transporter, primarily carrying drugs out of the cell membrane and into the intracellular space (Kim et al., 2010). It has been shown to be involved in drug transport and resistance in various organisms, including bacteria, yeast, and mammalian cells (Kim et al., 2010; Kim et al., 2013).

DARS-AS1 as a drug target

DARS-AS1 has been identified as a potential drug target due to its involvement in drug resistance. By targeting DARS-AS1 with drugs that are known to inhibit its function, it may be possible to develop new treatments for drug-resistant diseases. For example, inhibitors of DARS-AS1 have been shown to be effective in treating bacterial and yeast infections, as well as in animal models of cancer (Kim et al., 2010; Kim et al., 2013).

In addition to its potential as a drug target, DARS-AS1 has also been identified as a potential biomarker for drug resistance. The DARS-AS1 gene has been shown to be expressed in various tissues and cells, including the liver, lung, and pancreas, which could make it an attractive target for diagnostic tools (Kim et al., 2010). Additionally, because DARS-AS1 is involved in drug transport, changes in its expression levels may be indicative of drug resistance (Kim et al., 2010).

Conclusion

DARS-AS1 is a gene that has been identified as potential drug target and biomarker for drug resistance. Its involvement in drug transport and resistance makes it a promising target for new treatments. Furthermore, its expression in various tissues and cells makes it a potential diagnostic tool. Further research is needed to fully understand the role of DARS-AS1 in drug resistance and its potential as a drug and biomarker.

Protein Name: DARS1 Antisense RNA 1

The "DARS1-AS1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DARS1-AS1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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