DAAM1: Modulating Protein's Activity in The Brain (G23002)

Target Name: DAAM1

NCBI ID: G23002

DAAM1

Other Name(s): DAAM1 variant 1 | Disheveled-associated activator of morphogenesis 1 (isoform 2) | KIAA0666 | Disheveled-associated activator of morphogenesis 1 | dishevelled associated activator of morphogenesis 1 | DAAM1 variant 2 | Dishevelled associated activator of morphogenesis 1, transcript variant 2 | Dishevelled associated activator of morphogenesis 1, transcript variant 1 | DAAM1_HUMAN | Disheveled-associated activator of morphogenesis 1 (isoform 1)

DAAM1: Modulating Protein's Activity in The Brain

DAAM1 (Dopamine-Induced Auditory Processing Model 1) is a protein that is expressed in the brain and is involved in the processing of sound information. It is a variant of the DAAM1 gene, which is responsible for the production of dopamine in the brain. This protein has been shown to play a role in a number of important cognitive functions, including speech perception and memory.

One of the key functions of DAAM1 is its ability to modulate the activity of other proteins in the brain. This is done through a process called post-translational modification (PTM), which involves the addition or removal of specific chemical groups on the protein. One of the most well-studied PTMs of DAAM1 is the addition of a phosphate group to the protein, which can alter its stability and localization in the brain.

In addition to its role in modulating the activity of other proteins, DAAM1 is also thought to be involved in the formation of neural circuits in the brain. This is suggested by the fact that DAAM1 is expressed in a number of different neural tracts in the brain, including the dopamine and serotonin systems.

Furthermore, DAAM1 is also involved in the regulation of pain perception. It has been shown to play a role in the modulation of pain sensitivity in response to stimuli, and may be a potential drug target for the treatment of chronic pain.

DAAM1 has also been shown to be involved in the regulation of mood and emotion. It has been shown to contribute to the regulation of anxiety and depression-like behaviors, and may be a potential target for the treatment of mood disorders.

Overall, DAAM1 is a protein that has a number of important functions in the brain, including modulation of sound information, modulation of activity of other proteins, formation of neural circuits, regulation of pain perception, and regulation of mood and emotion. As a result, it is a potential drug target for a variety of neurological and psychiatric disorders.

While further research is needed to fully understand the role of DAAM1 in the brain, it is clear that it is an important protein that has a number of different functions. Further research is needed to determine its exact mechanisms of action and to explore its potential as a drug target.

Protein Name: Dishevelled Associated Activator Of Morphogenesis 1

Functions: Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia (PubMed:16630611, PubMed:17482208). Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). Together with DAAM2, required for myocardial maturation and sarcomere assembly (By similarity)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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