ZNF490: A Key Regulator of Neural Development and Function (G57474)

ZNF490: A Key Regulator of Neural Development and Function

ZNF490 (ZN490_HUMAN), a protein encoded by the ZNF4 gene, is a key regulator of neural development and function. The ZNF4 gene is located on chromosome 6 (6p) and has four exons (Exon 1-4) that encode the protein. ZNF490 is a 21-kDa protein that plays a crucial role in the development and maintenance of neural stem cells (NSCs), which are a vital source of diverse neural cell types for the entire nervous system.

The ZNF4 gene is a member of the ZNF gene family, which includes several similar genes, including ZNF2, ZNF3, ZNF4, and ZNF5. These genes are involved in the regulation of various cellular processes, including cell growth, differentiation, and inflammation. The ZNF4 gene is expressed in many tissues and organs, including brain, spinal cord, heart, and lymphoid organs.

ZNF490 is a key regulator of the neural stem cell cycle. It is well established that neural stem cells (NSCs) are a critical source of cells for the development and repair of the nervous system. NSCs are undifferentiated cells that have the ability to differentiate into various neural cell types, including neurons, glial cells, and other support cells. The regulation of the NSCs is critical for the development and maintenance of the nervous system, and the ZNF490 protein plays a crucial role in this process.

The ZNF490 protein has several unique features that make it an attractive drug target or biomarker. One of its most significant features is its ability to interact with various transcription factors, including NF-kappa-B, AP-1, and STAT3. This interaction between ZNF490 and these transcription factors allows the protein to regulate the expression of target genes and to influence cellular processes such as cell growth, differentiation, and survival.

Another feature of ZNF490 is its role in the regulation of the microtubule dynamics. Microtubules are important structural elements that organize the intracellular traffic of various cellular processes, including the transport of organelles, vesicles, and cytoskeletal components. The ZNF490 protein is involved in the regulation of microtubule dynamics and in the maintenance of the cytoskeleton integrity.

In addition to its role in cellular processes, ZNF490 is also a potent drug target because of its unique structure and the diverse range of functions it plays in various cellular processes. The ZNF490 protein is a small, 21-kDa protein that has a unique fusiform structure and a distinct C-terminus. This structure makes it a potential target for small molecules or antibodies that can interact with the protein and regulate its activity.

The ZNF490 protein is also a good candidate for biomarkers because of its expression in various tissues and its ability to regulate cellular processes that are relevant to the disease. For example, ZNF490 is expressed in the brain and is involved in the regulation of neurogenesis, which is the process by which new neurons are generated in the brain. In addition, ZNF490 is involved in the regulation of the immune response and has been implicated in the development of certain autoimmune diseases.

In conclusion, ZNF490 is a protein that has significant implications for the development and treatment of various diseases. Its unique structure and function as a regulator of the neural stem cell cycle and microtubule dynamics make it an attractive drug target or biomarker. Further research is needed to fully understand the role of ZNF490 in cellular processes and its potential as a therapeutic agent.

Protein Name: Zinc Finger Protein 490

Functions: May be involved in transcriptional regulation

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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   drug resistance;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

ZNF491 | ZNF492 | ZNF493 | ZNF496 | ZNF497 | ZNF497-AS1 | ZNF500 | ZNF501 | ZNF502 | ZNF503 | ZNF503-AS1 | ZNF503-AS2 | ZNF506 | ZNF507 | ZNF510 | ZNF511 | ZNF512 | ZNF512B | ZNF513 | ZNF514 | ZNF516 | ZNF516-DT | ZNF517 | ZNF518A | ZNF518B | ZNF519 | ZNF519P3 | ZNF521 | ZNF524 | ZNF525 | ZNF526 | ZNF527 | ZNF528 | ZNF528-AS1 | ZNF529 | ZNF529-AS1 | ZNF530 | ZNF532 | ZNF534 | ZNF536 | ZNF540 | ZNF541 | ZNF542P | ZNF543 | ZNF544 | ZNF546 | ZNF547 | ZNF548 | ZNF549 | ZNF550 | ZNF551 | ZNF552 | ZNF554 | ZNF555 | ZNF556 | ZNF557 | ZNF558 | ZNF559 | ZNF559-ZNF177 | ZNF560 | ZNF561 | ZNF561-AS1 | ZNF562 | ZNF563 | ZNF564 | ZNF565 | ZNF566 | ZNF566-AS1 | ZNF567 | ZNF568 | ZNF569 | ZNF56P | ZNF57 | ZNF570 | ZNF571 | ZNF571-AS1 | ZNF572 | ZNF573 | ZNF574 | ZNF575 | ZNF576 | ZNF577 | ZNF578 | ZNF579 | ZNF580 | ZNF582 | ZNF582-DT | ZNF583 | ZNF584 | ZNF585A | ZNF585B | ZNF586 | ZNF587 | ZNF587B | ZNF589 | ZNF592 | ZNF593 | ZNF594 | ZNF594-DT | ZNF595