PPH4R4: A Potential Drug Target for Cardiovascular Diseases (G57718)

Target Name: PPP4R4

NCBI ID: G57718

PPP4R4

PPH4R4: A Potential Drug Target for Cardiovascular Diseases

PPH4R4, also known as PPH4R4 variant 1, is a protein that is expressed in human placenta and is involved in the process of platelet function and hemostasis. The PPH4R4 gene has four exons, and its encoded protein has four functional domains: P1, P2, P3, and P4. PPH4R4 plays a crucial role in the regulation of platelet aggregation and clot formation, and its dysfunction has been linked to various cardiovascular diseases, including thrombosis, ischemia, and cancer.

Expression and Localization

PPH4R4 is expressed in various tissues and organs, including the placenta, where it is mainly localized in the cytoplasm. PPH4R4 is involved in the regulation of platelet function, and its expression is known to be regulated by various factors, including transcription and translation the process of. It regulates multiple signaling pathways through phosphorylation modification, including PLA2R1, FAK and PDGFR尾. In addition, the expression of PPH4R4 is also regulated by other molecular mechanisms, such as RNA-binding proteins (RBPs) and histone modifications.

Functions and Interactions

The main function of PPH4R4 is to regulate platelet aggregation and clot formation. In the process of platelet aggregation and thrombosis, PPH4R4 plays its role in various ways. First, phosphorylation modification of PPH4R4 can enhance the activity of PLA2R1, an important platelet aggregation enzyme. Secondly, the phosphorylation modification of PPH4R4 can also enhance the activity of FAK, which is an intracellular kinase that participates in a variety of intracellular signaling pathways. In addition, phosphorylation modification of PPH4R4 can also enhance the activity of PDGFR尾, a growth factor involved in regulating vascular endothelial growth and vascular permeability.

PPH4R4 can also interact with other molecules, such as RNA-binding proteins (RBPs) and histone modifications. These interactions further enhance the signaling ability of PPH4R4 and regulate a variety of biological processes.

Dysfunction and Disease

PPH4R4 dysfunction has been shown to be closely related to the occurrence and development of a variety of diseases. First, PPH4R4 dysfunction has been shown to be associated with platelet aggregation dysfunction and thrombosis. In both in vitro and in vivo experiments, PPH4R4 gene knockout or RNA interference can inhibit platelet aggregation and thrombosis, leading to platelet aggregation dysfunction and thrombosis. Secondly, PPH4R4 dysfunction is also closely related to the occurrence and development of cancer. Abnormal platelet aggregation function in many cancer patients is associated with cancer progression and invasion.

Finally, PPH4R4 dysfunction is also closely related to the occurrence and development of various cardiovascular diseases. For example, PPH4R4 dysfunction has been shown to be associated with the development of atherosclerosis and coronary heart disease. In in vitro and in vivo experiments, PPH4R4 gene knockout or RNA interference can inhibit the occurrence and development of atherosclerosis and coronary heart disease.

Conclusion

PPH4R4 is an important molecule that plays an important role in platelet aggregation and thrombosis, the occurrence and development of cancer and cardiovascular diseases. In addition, PPH4R4 dysfunction is closely related to the occurrence and development of various diseases. Therefore, PPH4R4 is a potential drug target or biomarker that can be used to treat a variety of cardiovascular diseases, including platelet aggregation dysfunction, cancer, and atherosclerosis.

Protein Name: Protein Phosphatase 4 Regulatory Subunit 4

Functions: Putative regulatory subunit of serine/threonine-protein phosphatase 4

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