Rad51D: A Non-Coding RNA Molecule Regulating DNA Replication and Gene Expression in Saccharomyces Cerevisiae

Target Name: RAD51D

NCBI ID: G5892

RAD51D

Rad51D: A Non-Coding RNA Molecule Regulating DNA Replication and Gene Expression in Saccharomyces Cerevisiae

Rad51D, also known as RAD51(S. cerevisiae)-like 3, is a non-coding RNA molecule that plays a crucial role in the regulation of gene expression in the yeast Saccharomyces cerevisiae. It is a key regulator of the DNA double helix, and its levels have been shown to be regulated in a variety of cellular processes, including DNA replication, repair, and transcription.

One of the key features of Rad51D is its ability to interact with DNA-binding proteins, including the enzyme responsible for initiating DNA replication, DNA polymerase I. This interaction between Rad51D and DNA-binding proteins is critical for the regulation of DNA replication, as errors in DNA replication can lead to genetic mutations and other cellular defects.

In addition to its role in DNA replication, Rad51D has also been shown to play a key role in the regulation of gene expression. It has been shown to interact with a variety of transcription factors, including the RNA polymerase II (RNA-II) complex, which is responsible for transcribing mRNA from DNA templates. This interaction between Rad51D and RNA-II allows Rad51D to regulate the levels of gene expression in the yeast cell.

Another promising aspect of Rad51D is its potential as a drug target. Its role in the regulation of gene expression makes it an attractive target for small molecule inhibitors, which can be used to treat a variety of cellular diseases, including cancer, neurodegenerative diseases, and genetic disorders. In addition, its ability to interact with DNA-binding proteins and transcription factors also makes it a potential target for small molecule inhibitors that target these proteins.

Overall, Rad51D is a non-coding RNA molecule that plays a crucial role in the regulation of gene expression in the yeast Saccharomyces cerevisiae. Its ability to interact with DNA-binding proteins and transcription factors makes it an attractive target for small molecule inhibitors, which can be used to treat a variety of cellular diseases. Further research is needed to fully understand the role of Rad51D in cellular processes, and to develop effective inhibitors for its unique functions.

Protein Name: RAD51 Paralog D

Functions: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM

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•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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