RAD54L: A Promising Drug Target for DNA Repair and Recombination

Target Name: RAD54L

NCBI ID: G8438

RAD54L

RAD54L: A Promising Drug Target for DNA Repair and Recombination

DNA repair and recombination are essential processes in the cell's DNA replication and maintenance. These processes help maintain genetic diversity, repair damaged DNA, and enable accurate genetic transmission. RAD54L, a protein that belongs to the Rad54 family, is a critical regulator of these processes. In this article, we will explore the biology of RAD54L, its functions in DNA repair and recombination, and its potential as a drug target.

Background

RAD54L, which has the gene symbol RAD54L1, is a 21-kDa protein that is expressed in various cell types. It is a part of the Rad54 family, which includes Rad54, Rad55, and Rad56, which are involved in various DNA repair and replication processes. RAD54L is composed of a unique nucleotide-binding domain, a transmembrane region, and a C-terminal region that contains a conserved GFP-like fluorescent protein.

Function

RAD54L is involved in several essential processes in DNA repair and recombination. It plays a critical role in the repair of DNA double-strand breaks, where it can recognize and repair the damage caused by the break. In addition, RAD54L is involved in the process of homologous recombination, which is the primary mechanism of DNA repair in eukaryotic cells. During homologous recombination, RAD54L helps to coordinate the exchange of genetic information between homologous chromosomes during meiosis.

RAD54L is also involved in the regulation of DNA replication. It has been shown to play a role in regulating the amount of DNA replicated in eukaryotic cells. This protein may also be involved in the regulation of gene expression by controlling the levels of chromatin accessible to transcription factors.

Potential as a Drug Target

The potential of RAD54L as a drug target is high due to its involvement in essential processes in DNA repair and replication. There is growing evidence that inhibitors of RAD54L can be effective in treating various diseases, including cancer, neurodegenerative diseases, and genetic disorders.

One of the reasons for the potential of RAD54L as a drug target is its unique structure. The N-terminal region of RAD54L contains a conserved GFP-like fluorescent protein, which can be used as a target for small molecules or antibodies. In addition, the C-terminal region of RAD54L contains a GFP-like gene that can be used for genetic modification of cells.

Another reason for the potential of RAD54L as a drug target is its involvement in various diseases. For example, RAD54L has been shown to be involved in the development and progression of various cancers, including breast, ovarian, and prostate cancers. In addition, RAD54L has also been implicated in the development of neurodegenerative diseases, including Alzheimer's and Parkinson's diseases.

In conclusion, RAD54L is a protein that plays a critical role in DNA repair and recombination. Its unique structure and involvement in various diseases make it an attractive drug target. Further research is needed to fully understand the biology of RAD54L and its potential as a drug.

Protein Name: RAD54 Like

Functions: Plays an essential role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks (PubMed:9774452, PubMed:24798879, PubMed:32457312, PubMed:11459989, PubMed:12205100, PubMed:27264870). Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Also plays an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA (By similarity)

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