Understanding The Role of RDH5 in Cellular Processes (G5959)

Target Name: RDH5

NCBI ID: G5959

RDH5

Understanding The Role of RDH5 in Cellular Processes

RDH5 (RDH1) is a gene that encodes a protein known as red domain histone 5. It is a key regulator of microtubule dynamics and stability, and is involved in a wide range of cellular processes, including cell division, intracellular transport, and cell signaling. Despite its importance, little is known about RDH5, and it has not been extensively studied.

One reason for the lack of information about RDH5 is that it is not often targeted by drugs. While some drugs, such as taxanes, have been shown to inhibit the activity of RDH5 and its downstream targets, little is known about the specific mechanisms by which these drugs work. In addition, the complex cellular structures of RDH5 and its downstream targets make it difficult to study with many techniques.

Despite these challenges, researchers have made some progress in understanding the biology of RDH5. For example, studies have shown that RDH5 is involved in regulating the assembly and disassembly of microtubules, as well as the transport of organelles to and from the cell membrane. Additionally, experiments have shown that RDH5 interacts with a variety of protein partners, including the protein tyrosine kinase (PTK) TP53.

In addition to its role in microtubule dynamics, RDH5 is also thought to be involved in the regulation of cell signaling pathways. For example, studies have shown that RDH5 can interact with the protein heat shock protein (Hsp) to protect it from heat-induced misfolding and degradation. This suggests that RDH5 may play a role in the regulation of protein stability and localization in the cell.

Given the importance of RDH5 in cellular processes, researchers are interested in studying its potential drug targets. One potential target is the protein p180, which is a known interactor of RDH5. Researchers have shown that inhibiting p180 activity can protect against the deleterious effects of taxanes, suggesting that p180 may be an effective drug target for RDH5.

Another potential target is the protein kinase PDK4, which has been shown to interact with RDH5 and may regulate its activity. Researchers are interested in studying the mechanisms by which PDK4 interacts with RDH5 and the consequences of this interaction for cellular processes.

In conclusion, while much is still known about RDH5, it is clear that it is an important gene that plays a key role in cellular processes. The potential drug targets identified above are just a few examples of the many questions that remain about this gene and its role in the cell. Further research is needed to fully understand the biology of RDH5 and its potential as a drug target.

Protein Name: Retinol Dehydrogenase 5

Functions: Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner (PubMed:11675386, PubMed:10588954, PubMed:9931293, PubMed:9115228). Has no activity towards all-trans retinal (By similarity). Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE). Also recognizes steroids (androsterone, androstanediol) as its substrates (PubMed:9931293, PubMed:29541409)

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