Discovering ATXN2 as A Drug Target for Neurodegenerative Diseases

Target Name: ATXN2

NCBI ID: G6311

ATXN2

Discovering ATXN2 as A Drug Target for Neurodegenerative Diseases

ATXN2 (Ataxin-2 isoform 1) is a protein that is expressed in most tissues of the body. It plays a critical role in the development and maintenance of neural networks, which are responsible for transmitting and processing information. ATXN2 is composed of two isoforms, ATXN2A and ATXN2B, which differ in their level of expression and localization. Despite its importance, little is known about ATXN2 and its potential functions.

The discovery of ATXN2 as a drug target

The study of ATXN2 as a drug target was motivated by the development of several neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, which are characterized by the progressive loss of brain cells. These diseases are associated with the accumulation of misfolded proteins, including ATXN2, which can lead to the formation of neurofibrillary tangles and the disruption of neural networks. Therefore, it is possible that targeting ATXN2 may be a promising strategy for the development of neurodegenerative diseases.

Several studies have suggested that ATXN2 may be a potential drug target by using various techniques, such as biochemical, cellular, and animal models. For example, some studies have shown that ATXN2 is involved in the development of neurofibrillary tangles in mouse models of Alzheimer's disease. Additionally, several studies have demonstrated that inhibiting the activity of ATXN2 can protect against the neurotoxicity of various neurodegenerative drugs, such as amyloid beta-peptides and tau aggregates.

Another approach to identify ATXN2 as a drug target is to use small molecules (such as drugs or natural compounds) that can interact with ATXN2 and modulate its activity. A number of compounds have been shown to interact with ATXN2 and modulate its function, including small molecules that can inhibit the activity of ATXN2 enzymes or modulate its stability.

Functional characterization of ATXN2

To better understand the function of ATXN2, researchers have used a variety of techniques to study its structure, function, and regulation. One of the most important findings is that ATXN2 is a protein that can form a disulfide bond, which is a covalent bond formed by the oxidation of a sulfur atom. This disulfide bond allows ATXN2 to form a stable dimer and can modulate its activity.

ATXN2 has been shown to play a critical role in the development and maintenance of neural networks, including the formation of axons and the regulation of synaptic plasticity. It is involved in the production of the neurotransmitter acetylcholine, which is critical for the development and maintenance of neural circuits. Additionally, ATXN2 is involved in the regulation of the growth and differentiation of neural cells, as well as the modulation of ion channels and neurotransmitter release.

The structure and function of ATXN2 have been studied using a variety of techniques, including biochemical, cellular, and structural studies. These studies have provided a detailed understanding of ATXN2's structure and function, as well as its regulation by various factors, including protein-protein interactions, tyrosination, and phosphorylation.

Targeting ATXN2

The discovery of ATXN2 as a drug target has led to a new era in the development of neurodegenerative diseases. Targeting ATXN2 with small molecules or antibodies has the potential to protect against the neurotoxicity of neurodegenerative drugs and slow the progression of these diseases.

In addition to the use of small molecules, researchers have also shown interest in using antibodies to target ATXN2. antibodies

Protein Name: Ataxin 2

Functions: Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane

The "ATXN2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ATXN2 comprehensively, including but not limited to:
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