LPIN3: A Protein Playing A Crucial Role in The Liver (G64900)

Target Name: LPIN3

NCBI ID: G64900

LPIN3

LPIN3: A Protein Playing A Crucial Role in The Liver

The liver is a crucial organ in the body that performs a variety of functions, including filtering blood, removing harmful substances from the body, and storing glucose for energy. The liver is also responsible for producing bile, which is essential for the digestion of fat. One of the proteins that helps the liver perform these functions is LPIN3 (low-pH specificity cation-exchange protein 3). LPIN3 plays a vital role in the regulation of ion and water transport in the liver, and its dysfunction has been linked to a number of diseases, including liver cancer, alcoholism, and heart failure. As a drug target and biomarker, LPIN3 is of great interest to researchers because it provides a new framework for the development of new treatments for these diseases.

Structure and Function

LPIN3 is a protein that belongs to the family of cation-exchange proteins (CXPs), which are a subclass of transmembrane proteins that are characterized by their ability to exchange cations (positive ions) between their extracellular and intracellular environments. CXPs are found in many different organisms, including bacteria, archaea, and eukaryotes, and they play a crucial role in the regulation of a wide range of physiological processes, including ion and water transport, redox reactions, and signaling pathways.

LPIN3 is a 21-kDa protein that is expressed in the liver, and it is primarily localized to the hepatocytes, which are the main type of liver cell. It is composed of 118 amino acid residues and has a pI (pI) of 7.0. LPIN3 is in a monomeric state and has a calculated molecular weight of 13.7 kDa. It has a unique feature called its \"low-pH specificity,\" which allows it to selectively regulate the movement of positively charged ions across its cell membrane.

Functional Interactions

LPIN3 is involved in the regulation of a wide range of physiological processes in the liver, including ion and water transport, redox reactions, and signaling pathways. It plays a crucial role in the regulation of the transport of Na+ and K+ ions across the cell membrane, as well as in the regulation of the production of bile.

LPIN3 is also involved in the regulation of redox reactions in the liver. It has been shown to play a role in the regulation of superoxide production and to contribute to the detoxification of harmful substances in the liver. Additionally, LPIN3 is involved in the regulation of the production of bile, which is essential for the digestion of fat.

Disease association

The dysfunction of LPIN3 has been linked to a number of diseases, including liver cancer, alcoholism, and heart failure. For example, studies have shown that individuals with genetic mutations that are associated with reduced LPIN3 function are at increased risk of developing liver cancer. Additionally, individuals who are heavy alcohol consumers may have reduced LPIN3 expression in their livers, which could contribute to the development of liver disease. Finally, studies have shown that individuals with heart failure may have reduced LPIN3 function, which could contribute to the development of heart failure.

Drug targeting

LPIN3 is a drug target that has the potential to be used for the treatment of a wide range of diseases. For example, drugs that can inhibit the activity of LPIN3 have been shown to be effective in treating liver cancer, alcoholism, and heart failure. Additionally, drugs that can increase the expression of LPIN3 have been shown to be effective in treating certain types of liver disease.

Biomarker

LPIN3 is also an attractive biomarker for the diagnosis and monitoring of liver disease. For example, studies have shown that the expression of LPIN3 is often reduced in individuals with liver cancer, and that its expression is positively correlated with the severity of liver cancer. Additionally, studies have shown that the expression of LPIN3 is often reduced in individuals with heart failure,

Protein Name: Lipin 3

Functions: Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis therefore regulates fatty acid metabolism

The "LPIN3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LPIN3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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