LRAT Gene: Potential Drug Target Or Biomarker for Obesity, Type 2 Diabetes and Cardiovascular Disease

Target Name: LRAT

NCBI ID: G9227

LRAT

LRAT Gene: Potential Drug Target Or Biomarker for Obesity, Type 2 Diabetes and Cardiovascular Disease

LRAT (Lecithin-retinol acyltransferase) is a gene that has been identified as a potential drug target or biomarker for several diseases, including obesity, type 2 diabetes, and cardiovascular disease. Lecithin is a natural compound that is found in all cell types and is known for its ability to lower cholesterol levels. Retinol is a form of vitamin A that is also known for its ability to lower cholesterol levels and is often used in treatments for macular degeneration.

The LRAT gene has been shown to play a role in the production of lecithin, which is a major cholesterol-lowering agent in the body. Lecithin is synthesized in the liver and is also obtained from dietary sources such as algae, fungi, and bacteria. It is formed from the amino acids lecithin, hyphaein, and betaglionin.

Research has shown that individuals with certain genetic variations in the LRAT gene are at a higher risk for developing obesity and type 2 diabetes. These genetic variations have been associated with decreased levels of lecithin in the body.

Additionally, LRAT has also been linked to cardiovascular disease. Studies have shown that individuals with certain genetic variations in the LRAT gene are at a higher risk for developing cardiovascular disease. This is thought to be due to the fact that Lecithin plays a role in the production of low-density lipoprotein (LDL) cholesterol, which is a major risk factor for cardiovascular disease.

Despite the potential benefits of LRAT as a drug target or biomarker, more research is needed to fully understand its role in the development and progression of obesity, type 2 diabetes, and cardiovascular disease.

In conclusion, LRAT is a gene that has been identified as a potential drug target or biomarker for several diseases, including obesity, type 2 diabetes, and cardiovascular disease. Further research is needed to fully understand its role in the development and progression of these conditions.

Protein Name: Lecithin Retinol Acyltransferase

Functions: Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters (PubMed:9920938). Retinyl esters are storage forms of vitamin A (Probable). LRAT plays a critical role in vision (Probable). It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments (Probable). Required for the survival of cone photoreceptors and correct rod photoreceptor cell morphology (By similarity)

The "LRAT Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LRAT comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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