Unlocking The Potential of Metallo Phosphoesterase MPPE1 (G65258)

Target Name: MPPE1

NCBI ID: G65258

MPPE1

Unlocking The Potential of Metallo Phosphoesterase MPPE1

Metallo phosphoesterase (MPPE1) is a protein that is expressed in a variety of cell types, including neurons, muscle cells, and liver cells. It is an enzymes that catalyzes the phosphate orylation of metal ions, such as calcium, magnesium, and zinc. This reaction is a critical step in the regulation of a wide range of cellular processes, including muscle contractions, nerve signal transduction, and hormone signaling.

One of the unique features of MPPE1 is its catalytic mechanism. It is a monomeric protein that consists of a single alpha-helic acid domain. This domain is responsible for the catalytic activity of the enzyme, as well as its ability to interact with metal ions . The alpha-helic acid domain has a characteristic Rossmann-fold that allows it to bind to metal ions with high affinity. This is why MPPE1 is able to catalyze the phosphate orylation of a wide range of metals, including those that are involved in signaling pathways that are important for cellular processes.

One of the things that makes MPPE1 an attractive drug target is its role in the regulation of muscle contractions. Muscle contractions are critical for many of the physiological functions that we rely on, such as movement, balance, and voice production. MPPE1 is involved in the regulation of muscle contractions by phosphorating the myosin heads, which are the structural units that give muscle cells their shape and generate the force of muscle contractions. This is why MPPE1 inhibitors have been shown to be effective in treating a variety of muscle-related conditions, including spinal muscular atrophy and myopathies.

Another potential application of MPPE1 as a drug target is its role in the regulation of neurotransmitter signaling. Neurotransmitters are the chemicals that are used by the brain and nervous system to communicate with messenger other cells. MPPE1 is involved in the regulation of the phosphorylation of neurotransmitters. , which is critical for the stability and efficacy of these molecules. This is why MPPE1 inhibitors have been shown to be effective in treating a variety of neurotransmitter-related conditions, including depression, anxiety, and neurodegenerative diseases.

In addition to its role in muscle and neurotransmitter regulation, MPPE1 is also involved in the regulation of other cellular processes that are important for overall cellular health and survival. For example, it is involved in the regulation of cell signaling pathways, DNA replication, and apoptosis (programmed cell death). This is why MPPE1 inhibitors have been shown to have a variety of potential applications in cancer treatment, as well as the treatment of other diseases that are characterized by the regulation of cellular processes.

Overall, MPPE1 is a protein that is involved in a wide range of cellular processes that are important for overall cellular health and survival. Its catalytic activity as an enzyme makes it an attractive target for drug development, as does its role in the regulation of muscle and neurotransmitter signaling. As more research is conducted on MPPE1, it is likely that new treatments and therapies will be discovered that can improve the health and quality of life for many individuals.

Protein Name: Metallophosphoesterase 1

Functions: Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins

The "MPPE1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MPPE1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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