LAPTM5: A Potential Drug Target and Biomarker (G7805)

Target Name: LAPTM5

NCBI ID: G7805

LAPTM5

LAPTM5: A Potential Drug Target and Biomarker

Introduction

LAPTM5 (Ligand-Activated Phosphatidylserine Transferase 5) is a protein that is expressed in various tissues and cell types in the human body. It is involved in the intracellular signaling pathway known as the phosphatidylinositol (PMA) signaling pathway. This pathway is crucial for various cellular processes, including cell signaling, cytoskeletal organization, and intracellular transport. LAPTM5 has been identified as a potential drug target and biomarker due to its unique structure, function, and involvement in disease.

Structure and Function

LAPTM5 is a 21-kDa protein that consists of 121 amino acid residues. It has a unique fold, with a catalytic core and a distinct N-terminus. The catalytic core of LAPTM5 consists of a parallel beta-sheet, which is flanked by alpha -helices that contain the active site for phosphatidylserine transfer. The N-terminus of LAPTM5 contains a putative N-endopeptide that is involved in the formation of a N-end-anchored complex with the protein p120GAP.

LAPTM5 is involved in the PMA signaling pathway, which is a critical pathway for cell signaling and survival. The PMA pathway is a complex process that involves the transfer of phosphatidylserine (PS) to various cellular signaling pathways. The transfer of PS from LAPTM5 to p120GAP is a critical step in the PMA pathway, as it allows the formation of the N-end-anchored complex that regulates various cellular processes.

LAPTM5 is also involved in the regulation of cellular processes such as cell adhesion, migration, and invasion. Studies have shown that LAPTM5 plays a crucial role in the regulation of tight junction formation and the formation of tight junctions with cancer cells. It is also involved in the regulation of cell proliferation and apoptosis.

Due to its unique structure and function, LAPTM5 has been identified as a potential drug target. The use of small molecules, such as inhibitors of LAPTM5, has been shown to have therapeutic effects on various cellular processes. For example, inhibitors of LAPTM5 have been shown to inhibit the migration and invasion of cancer cells.

In addition to its potential therapeutic uses, LAPTM5 has also been identified as a potential biomarker. The levels of LAPTM5 have been shown to be elevated in various diseases, including cancer. This suggests that LAPTM5 may be a useful biomarker for the diagnosis and treatment of these diseases.

Molecular Mechanisms

The molecular mechanisms underlying the function of LAPTM5 are not well understood. However, studies have shown that LAPTM5 is involved in the regulation of various cellular processes, including cell signaling, cytoskeletal organization, and intracellular transport.

One of the key mechanisms by which LAPTM5 functions is through its role in the regulation of the PMA pathway. Studies have shown that LAPTM5 is involved in the transfer of phosphatidylserine to p120GAP, which is the protein that initiates the PMA pathway. This transfer of PS to p120GAP allows the formation of the N-end-anchored complex, which regulates various cellular processes.

In addition to its role in the PMA pathway, LAPTM5 is also involved in the regulation of cellular processes such as cell adhesion and migration. Studies have shown that LAPTM5 plays a

Protein Name: Lysosomal Protein Transmembrane 5

Functions: May have a special functional role during embryogenesis and in adult hematopoietic cells

The "LAPTM5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LAPTM5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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