The ACSS3: A Drug Target and Biomarker for Mitochondrial Disorders

Target Name: ACSS3

NCBI ID: G79611

ACSS3

The ACSS3: A Drug Target and Biomarker for Mitochondrial Disorders

Mitochondrial disorders are a group of genetic disorders caused by defects in the mitochondria, which are energy-producing structures inside our cells. These disorders can result in a range of symptoms, including muscle weakness, liver disease, and cognitive impairments. The Acyl-CoA synthetase short-chain family member 3 (ACSS3) is a protein that plays a crucial role in the structure and function of the mitochondria. In this article, we will explore ACSS3 as a drug target and biomarker for mitochondrial disorders.

ACSS3: Structure and Function

ACSS3 is a member of the Acyl-CoA synthetase family, which is a well-known protein that is involved in the synthesis of long-chain fatty acids from the amino acids acetyl-CoA. This process is essential for the production of energy in the mitochondria. In addition to its role in energy metabolism, ACSS3 is involved in the regulation of cellular processes that are critical for cell survival, such as stress response, apoptosis, and autophagy.

ACSS3 is a 21-kDa protein that consists of 205 amino acids. It has a unique structure that is characterized by a long amino acid tail, a single transmembrane segment, and a N-terminal coiled-coil. The protein is expressed in most tissues and cells in the body, including the heart, liver, and brain. It is primarily localized to the mitochondria, where it is involved in the synthesis of fatty acids and the regulation of cellular processes that are critical for cell survival.

ACSS3 functions as a critical regulator of mitochondrial physiology and is involved in a wide range of cellular processes that are critical for cell survival and function. One of its most well-known functions is its role in the production of long-chain fatty acids, which are essential for the production of energy in the mitochondria. In addition to its role in energy metabolism, ACSS3 is also involved in the regulation of cellular processes that are critical for cell survival, such as stress response, apoptosis, and autophagy.

ACSS3 is also involved in the regulation of cellular signaling pathways that are critical for cell growth and development. One of its most well-known functions is its role in the regulation of the unfolded-protein response (UPR), a process that is critical for the regulation of protein structure and function. UPR is a critical regulatory pathway that is involved in the regulation of protein stability and function, and ACSS3 is involved in its regulation.

Drug Targeting and Biomarker

ACSS3 is a potential drug target for a wide range of mitochondrial disorders. Its role in the production of long-chain fatty acids and the regulation of energy metabolism make it an attractive target for drugs that are designed to improve energy metabolism. In addition, ACSS3 is involved in the regulation of cellular signaling pathways that are critical for cell growth and development, making it an attractive target for drugs that are designed to promote cell growth and development.

ACSS3 is also a potential biomarker for a wide range of mitochondrial disorders. Its role in the production of long-chain fatty acids and the regulation of energy metabolism make it an attractive target for diagnostic tests that are designed to measure these processes. In addition, ACSS3 is involved in the regulation of cellular signaling pathways that are critical for cell growth and development, making it an attractive target for diagnostic tests that are designed to measure these processes.

Conclusion

In conclusion, ACSS3 is a protein that plays a crucial role in the structure and function of the mitochondria. Its role in energy metabolism and the regulation of cellular processes that are critical for

Protein Name: Acyl-CoA Synthetase Short Chain Family Member 3

Functions: Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:28003429). Propionate is the preferred substrate (PubMed:28003429). Can utilize acetate and butyrate with a much lower affinity (By similarity)

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