PRIM1: A Protein Involved in Brain Function and Disease (G5557)

Target Name: PRIM1

NCBI ID: G5557

PRIM1

PRIM1: A Protein Involved in Brain Function and Disease

PRIM1 (PRIM1-12308) is a protein that is expressed in various tissues of the body, including the brain, heart, liver, and kidneys. It is a member of the PRIM family of proteins, which are known for their role in intracellular signaling. PRIM1 has been shown to play a role in the regulation of cellular processes that are important for brain function, including the development and maintenance of neural networks and the regulation of neurotransmitter signaling.

One of the key functions of PRIM1 is its role in the regulation of synaptic plasticity, which is the ability of the brain to change and adapt in response to experience. PRIM1 has been shown to play a role in the formation of synaptic plasticity in the brain, as well as in the regulation of synaptic plasticity in other tissues.

In addition to its role in synaptic plasticity, PRIM1 has also been shown to play a role in the regulation of cellular signaling pathways that are important for a variety of cellular processes, including cell growth, apoptosis (programmed cell death), and inflammation.

Given its role in a variety of cellular processes, PRIM1 has been identified as a potential drug target for a variety of diseases. For example, PRIM1 has been shown to be involved in the regulation of neurotransmitter signaling in conditions such as Alzheimer's disease, Parkinson's disease, and depression. It has also been shown to play a role in the regulation of cell growth and apoptosis in a variety of cancer types.

In addition to its potential as a drug target, PRIM1 has also been shown to be a potential biomarker for a variety of diseases. For example, it has been shown to be elevated in the brains of individuals with Alzheimer's disease, and it has been used as a biomarker for cancer in a variety of studies.

Overall, PRIM1 is a protein that has important roles in a variety of cellular processes, including synaptic plasticity and cellular signaling pathways. As a result, it has been identified as a potential drug target and biomarker for a variety of diseases. Further research is needed to fully understand the role of PRIM1 in these processes and to develop effective treatments for these diseases.

Protein Name: DNA Primase Subunit 1

Functions: Catalytic subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex - primosome/replisome) which play an essential role in the initiation of DNA synthesis (PubMed:9268648, PubMed:9705292, PubMed:17893144, PubMed:24043831, PubMed:26975377, PubMed:25550159, PubMed:31479243, PubMed:33060134). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (PubMed:17893144). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (PubMed:17893144). Synthesizes 9-mer RNA primers (also known as the 'unit length' RNA primers). Incorporates only ribonucleotides in the presence of ribo- and deoxy-nucleotide triphosphates (rNTPs, dNTPs) (PubMed:26975377). Requires template thymine or cytidine to start the RNA primer synthesis, with an adenine or guanine at its 5'-end (PubMed:25550159, PubMed:26975377). Binds single stranded DNA (By similarity)

The "PRIM1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PRIM1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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