PRIM2: The Potential Drug Target for DNA Primase Large Subunit

Target Name: PRIM2

NCBI ID: G5558

PRIM2

PRIM2: The Potential Drug Target for DNA Primase Large Subunit

DNA primase large subunit (PRIM2) is a protein that plays a critical role in the process of DNA replication. It is a large subunit of the DNA replication complex, which is responsible for copying the double-stranded DNA template to the two daughter strands during the process of DNA replication. PRIM2 is a key protein that helps ensure the accuracy and efficiency of DNA replication by regulating the movement of the replication complex along the double-stranded DNA template.

The Importance of PRIM2 in DNA Replication

PRIM2 is a key protein that helps ensure the accuracy and efficiency of DNA replication by regulating the movement of the replication complex along the double-stranded DNA template. It does this by playing a critical role in the structure and function of the replication complex.

The replication complex is a complex of proteins that work together to ensure the accurate and efficient copying of the double-stranded DNA template during the process of DNA replication. The replication complex includes several proteins, including PRIM2, which is a key protein that helps ensure the accuracy and efficiency of DNA replication.

PRIM2 Regulates the Movement of the Replication Complex

PRIM2 is a key protein that helps regulate the movement of the replication complex along the double-stranded DNA template. It does this by playing a critical role in the structure and function of the replication complex.

One of the key functions of PRIM2 is to regulate the movement of the replication complex along the double-stranded DNA template. This is done by playing a critical role in the structure and function of the replication complex.

PRIM2 Contributes to the Stability of the Replication Complex

PRIM2 is also a key protein that contributes to the stability of the replication complex. This is done by playing a critical role in the structure and function of the replication complex.

The replication complex is a complex of proteins that work together to ensure the accurate and efficient copying of the double-stranded DNA template during the process of DNA replication. The replication complex includes several proteins, including PRIM2, which is a key protein that helps ensure the accuracy and efficiency of DNA replication.

PRIM2 Helps Ensure the Double-Stranded DNA Template

PRIM2 is also a key protein that helps ensure the double-stranded DNA template during the process of DNA replication. This is done by playing a critical role in the structure and function of the replication complex.

The double-stranded DNA template is the template that is used to create a new double-stranded DNA molecule during the process of DNA replication. PRIM2 is a key protein that helps ensure that the double-stranded DNA template is stable and that it is accurately copied during the process of DNA replication.

PRIM2 as a Drug Target

PRIM2 is a large subunit of the DNA replication complex, and it is involved in the regulation of DNA replication. As a result, PRIM2 is a potential drug target.

The development of new drugs that target PRIM2 is an exciting area of research, as it has the potential to lead to new treatments for a variety of diseases. PRIM2 is a key protein that plays a critical role in the process of DNA replication, and targeting it with drugs could be an effective way to treat a variety of diseases.

Conclusion

In conclusion, PRIM2 is a protein that plays a critical role in the process of DNA replication. It is a key protein that helps ensure the accuracy and efficiency of DNA replication by regulating the movement of the replication complex along the double-stranded DNA template. As a result, PRIM2 is a potential drug target, and research into its potential uses in treating

Protein Name: DNA Primase Subunit 2

Functions: Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis (PubMed:9705292, PubMed:17893144, PubMed:25550159, PubMed:26975377). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (PubMed:17893144). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (PubMed:17893144, PubMed:25550159). Binds RNA:DNA duplex and coordinates the catalytic activities of PRIM1 and POLA2 during primase-to-polymerase switch

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