TET1: A Zinc Finger Protein as a Potential Drug Target and Biomarker
TET1: A Zinc Finger Protein as a Potential Drug Target and Biomarker
Abstract: Tetratetrahedral zinc finger proteins (TETs) are a family of non-coding RNAs that play crucial roles in various cellular processes. TET1, a zinc finger protein located in the human chromome, is a key regulator of cell proliferation and has been implicated in several diseases. This article summarizes the findings related to TET1, its potential drug target properties, and its role as a biomarker in various diseases.
Introduction:
Zinc finger proteins (ZFPs) are a family of non-coding RNAs that contain a conserved zinc finger motif. ZFPs have been implicated in various cellular processes, including DNA replication, gene expression, and cell signaling pathways. One of the subfamilies of ZFPs, the Tetratetrahedral ZFPs (TETs), have been particularly well-studied due to their unique structure and function. TETs are characterized by their four-digit arrangement of zinc fingers, which gives them the name \"tetrahedral.\"
TET1, a zinc finger protein located in the human chromosome (chr17), has been extensively studied for its functions in various cellular processes. Tetratetrahedral zinc finger proteins (TETs) have been shown to play crucial roles in cell signaling pathways, including cell proliferation, apoptosis, and inflammation.
Potential Drug Target:
Tetratetrahedral zinc finger proteins (TETs) have been identified as potential drug targets due to their unique structure and function. Tetratetrahedral zinc finger protein 6 (TET1) is a key regulator of cell proliferation and has been shown to play a role in the development of various diseases, including cancer.
TET1 has been shown to regulate cell cycle progression, apoptosis, and cell survival. Tetratetrahedral zinc finger protein 6 (TET1) has been shown to promote the G1 phase of the cell cycle and inhibit the S phase. This regulation of the cell cycle is crucial for the development and progression of cancer.
In addition to its role in cell cycle regulation, Tetratetrahedral zinc finger protein 6 (TET1) has also been shown to play a role in cell apoptosis. Tetratetrahedral zinc finger protein 6 (TET1) has been shown to promote apoptosis in various cell types, including cancer cells.
Potential Biomarkers:
Tetratetrahedral zinc finger protein 6 (TET1) has also been shown to serve as a potential biomarker for various diseases, including cancer. Tetratetrahedral zinc finger protein 6 (TET1) has been shown to be expressed in various tissues and has been used as a biomarker for several diseases, including cancer.
Conclusion:
Tetratetrahedral zinc finger protein 6 (TET1) is a zinc finger protein that has been extensively studied for its functions in various cellular processes. Tetratetrahedral zinc finger protein 6 (TET1) has been shown to regulate cell cycle progression, apoptosis, and cell survival, and has been implicated in the development and progression of cancer.
Tetratetrahedral zinc finger protein 6 (TET1) has also been shown to serve as a potential biomarker for various diseases, including cancer. Given its unique structure and function, Tetratetrahedral zinc finger protein 6 (TET1) has the potential to be a drug target and a biomarker for various diseases. Further research is needed to fully understand the functions of Tetratetrahedral zinc finger protein 6 (TET1) and its potential as a drug
Protein Name: Tet Methylcytosine Dioxygenase 1
Functions: Dioxygenase that plays a key role in active DNA demethylation, by catalyzing the sequential oxidation of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) (PubMed:19372391, PubMed:21496894, PubMed:21778364, PubMed:35798741). In addition to its role in DNA demethylation, plays a more general role in chromatin regulation by recruiting histone modifying protein complexes to alter histone marks and chromatin accessibility, leading to both activation and repression of gene expression (PubMed:33833093). Plays therefore a role in many biological processes, including stem cell maintenance, T- and B-cell development, inflammation regulation, genomic imprinting, neural activity or DNA repair (PubMed:31278917). Involved in the balance between pluripotency and lineage commitment of cells and plays a role in embryonic stem cells maintenance and inner cell mass cell specification. Together with QSER1, plays an essential role in the protection and maintenance of transcriptional and developmental programs to inhibit the binding of DNMT3A/3B and therefore de novo methylation (PubMed:33833093). May play a role in pancreatic beta-cell specification during development. In this context, may function as an upstream epigenetic regulator of PAX4 presumably through direct recruitment by FOXA2 to a PAX4 enhancer to preserve its unmethylated status, thereby potentiating PAX4 expression to adopt beta-cell fate during endocrine lineage commitment (PubMed:35798741). Under DNA hypomethylation conditions, such as in female meiotic germ cells, may induce epigenetic reprogramming of pericentromeric heterochromatin (PCH), the constitutive heterochromatin of pericentromeric regions. PCH forms chromocenters in the interphase nucleus and chromocenters cluster at the prophase of meiosis. In this context, may also be essential for chromocenter clustering in a catalytic activity-independent manner, possibly through the recruitment polycomb repressive complex 1 (PRC1) to the chromocenters (By similarity). During embryonic development, may be required for normal meiotic progression in oocytes and meiotic gene activation (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034)
The "TET1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TET1 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
TET2 | TET2-AS1 | TET3 | Tetraspanin | TEX10 | TEX101 | TEX11 | TEX12 | TEX13A | TEX13B | TEX13C | TEX14 | TEX15 | TEX19 | TEX2 | TEX21P | TEX22 | TEX26 | TEX261 | TEX264 | TEX28 | TEX29 | TEX30 | TEX33 | TEX35 | TEX36 | TEX36-AS1 | TEX37 | TEX38 | TEX41 | TEX43 | TEX44 | TEX45 | TEX46 | TEX47 | TEX48 | TEX49 | TEX50 | TEX52 | TEX53 | TEX55 | TEX56P | TEX9 | TF | TFAM | TFAMP1 | TFAP2A | TFAP2A-AS1 | TFAP2A-AS2 | TFAP2B | TFAP2C | TFAP2D | TFAP2E | TFAP4 | TFB1M | TFB2M | TFCP2 | TFCP2L1 | TFDP1 | TFDP1P2 | TFDP2 | TFDP3 | TFE3 | TFEB | TFEC | TFF1 | TFF2 | TFF3 | TFG | TFIID Basal Transcription Factor Complex | TFIIIC2 complex | TFIP11 | TFIP11-DT | TFPI | TFPI2 | TFPT | TFR2 | TFRC | TG | TGDS | TGFA | TGFA-IT1 | TGFB1 | TGFB1I1 | TGFB2 | TGFB2-AS1 | TGFB3 | TGFBI | TGFBR1 | TGFBR2 | TGFBR3 | TGFBR3L | TGFBRAP1 | TGIF1 | TGIF2 | TGIF2-RAB5IF | TGIF2LX | TGIF2LY | TGM1 | TGM2
