RPBP7: A Non-Code RNA Molecule Regulating Protein Synthesis and Stability

Target Name: RRP7BP

NCBI ID: G91695

RRP7BP

Other Name(s): ribosomal RNA processing 7 homolog B, pseudogene | Ribosomal RNA processing 7 homolog B, pseudogene | RRP7B | dJ222E13.2

RPBP7: A Non-Code RNA Molecule Regulating Protein Synthesis and Stability

Ribosomal RNA processing 7 homolog B (RPBP7) is a non-coding RNA molecule that plays an important role in the process of gene expression. It is a key regulator of protein synthesis and has been implicated in various diseases, including cancer, neurodegenerative diseases, and developmental disorders. Despite its potential as a drug target, much of the research on RPBP7 remains unexplored, and its functions and interactions with proteins are not well understood.

RPBP7 is a member of the Ribosomal RNA Processing 7 gene family, which is located on chromosome 18q21. It is a small RNA molecule that contains 73 amino acid residues and has a calculated molecular weight of 19.1 kDa. RPBP7 is expressed in various cell types and tissues, including muscle, heart, brain, and organs, and has been shown to play a role in regulating gene expression in these organisms.

Function

RPBP7 is involved in the process of gene expression by regulating the translation of mRNAs into proteins. It does this by interacting with a protein called TRIF2, which is a key regulator of protein synthesis. TRIF2 is a nucleotide-binding protein that plays a role in the initiation of the translation process by binding to a specific recognition site on the mRNA. RPBP7 has been shown to interact with TRIF2 and prevent it from binding to the recognition site, thereby inhibiting protein synthesis.

RPBP7 has also been shown to play a role in the regulation of protein stability and degradation. It has been shown to interact with the protein known as NOL1 and promote the formation of a protein-protein interaction complex, thereby leading to increased stability and resistance to degradation of certain proteins.

RPBP7 has also been shown to play a role in the regulation of cellular processes such as cell growth, apoptosis, and autophagy. It has been shown to promote the growth of certain cell types and to play a role in the regulation of cell death in response to environmental stresses, such as starvation and radiation.

RPBP7 has also been shown to play a role in the regulation of gene expression in the nervous system. It has been shown to interact with the protein known as Calbindin and promote the formation of a protein-protein interaction complex, thereby contributing to the regulation of neural development and function.

Drug targeting

RPBP7 is a promising drug target due to its involvement in various cellular processes that are often disrupted in diseases. Its involvement in the regulation of protein synthesis, stability, and degradation makes it a potential target for small molecules, antibodies, or other therapeutic agents that can modulate its activity.

One approach to targeting RPBP7 is to use small molecules that interact with TRIF2 and prevent it from binding to the recognition site. Such molecules have been shown to be effective in promoting protein stability and have been shown to interact with TRIF2 in a similar way.

Another approach to targeting RPBP7 is to use antibodies that recognize and specifically bind to it. Such antibodies have been shown to be effective in inhibiting the activity of TRIF2 and have been shown to promote the formation of a protein-protein interaction complex with RPBP7.

Conclusion

RPBP7 is a non-coding RNA molecule that plays a critical role in the regulation of gene expression and has been implicated in various diseases. Its functions and interactions with proteins are not well understood, and there is a need for further research to fully understand its role in cellular processes and its potential as a drug target. Further studies are needed to determine the best way to target RPBP7 and to develop effective therapies based on its properties.

Protein Name: Ribosomal RNA Processing 7 Homolog B, Pseudogene

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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