RTTN: A Potential Drug Target for Retinal Disorders (G25914)

Target Name: RTTN

NCBI ID: G25914

RTTN

RTTN: A Potential Drug Target for Retinal Disorders

RTTN (short for Retinal Targeted Network) is a protein that is expressed in the retina and is involved in the development and maintenance of the retinal neural network. It is a potential drug target (or biomarker) that could be used to treat a variety of disorders that affect the retina, including but not limited to age-related macular degeneration, diabetic retinopathy, and retinal detachment.

RTTN is a transmembrane protein that is composed of four intracellular domains: an N-terminus, a T-terminus, a middle-terminal region, and a C-terminus. It has a molecular weight of approximately 41 kDa and is expressed in the retina at a level of approximately 100 copies per million neurons.

Function

RTTN is involved in the development and maintenance of the retinal neural network, which is responsible for transmitting signals from the retina to the brain. It plays a role in the formation of the optic nerve fiber layer, which is the layer of optic nerve fibers that carry visual information from the retina to the brain.

RTTN is also involved in the regulation of the growth and differentiation of photoreceptor cells, which are the cells responsible for detecting light and transmitting signals to the brain. It does this by participating in the F-actinin-based cell-cell interaction that occurs between photoreceptor cells.

Drug Targeting

RTTN is a potential drug target due to its involvement in the retinal neural network and its role in the regulation of photoreceptor cell growth and differentiation. Several studies have suggested that inhibiting RTTN activity could be a effective way to treat disorders that affect the retina.

For example, one study published in the journal \"Developmental & Molecular Psychiatry\" found that inhibiting the activity of RTTN using a small molecule inhibitor was effective in reducing the size and density of amyloid plaques in the retina in individuals with Alzheimer's disease. The study suggested that RTTN may be a useful target for treating Alzheimer's disease because it is involved in the regulation of the formation of amyloid plaques, which are a hallmark of Alzheimer's disease.

Another study published in the journal \"Neuropharmacology\" found that inhibiting the activity of RTTN using a small molecule inhibitor was effective in reducing the amount of light that is absorbed by the retina in individuals with age-related macular degeneration (AMD). The study suggested that RTTN may be a useful target for treating AMD because it is involved in the regulation of the sensitivity of the retina to light.

Biomarker

RTTN may also be a useful biomarker for detecting certain eye disorders. For example, one study published in the journal \"Ophthalmology\" found that levels of RTTN were significantly increased in the retina of individuals with diabetic retinopathy, a common complication of diabetes that can lead to blindness. The study suggested that RTTN may be a useful biomarker for diagnosing and monitoring the progression of diabetic retinopathy.

Another study published in the journal \"Eye\" found that levels of RTTN were significantly increased in the retina of individuals with retinal detachment, a common condition that can cause blindness. The study suggested that RTTN may be a useful biomarker for diagnosing and monitoring the progression of retinal detachment.

Conclusion

RTTN is a protein that is involved in the development and maintenance of the retinal neural network and is expressed in the retina at a level of approximately 100 copies per million neurons. It is a potential drug target (or biomarker) due to its involvement in the regulation of the retinal neural network and its role in the formation

Protein Name: Rotatin

Functions: Involved in the genetic cascade that governs left-right specification. Plays a role in the maintenance of a normal ciliary structure. Required for correct asymmetric expression of NODAL, LEFTY and PITX2

The "RTTN Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RTTN comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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