TNFSF14: A Potential Drug Target and Biomarker (G8740)

Target Name: TNFSF14

NCBI ID: G8740

TNFSF14

TNFSF14: A Potential Drug Target and Biomarker

Tumor necrosis factor (TNF) superfamily member 14 (TNF-14) is a protein that plays a crucial role in cellular signaling and inflammation. It is a cytoplasmic protein that is expressed in a variety of tissues, including the immune system, skeletal muscles, and epithelial tissues. TNF-14 is involved in the regulation of cellular processes such as cell adhesion, migration, and survival.

One of the key functions of TNF-14 is its role in cancer progression. It has been shown to promote the growth and survival of a variety of cancer cells, including breast, ovarian, and colorectal cancers. TNF-14 has also been shown to play a role in the development of metastasis.

Despite the potential implications of TNF-14's role in cancer, it is not yet a well-established drug target. However, there is ongoing research into using TNF-14 as a potential drug target or biomarker.

One approach to using TNF-14 as a drug target is to target its role in cell signaling and inflammation. TNF-14 has been shown to play a role in the regulation of cellular signaling pathways, including the TGF-β pathway. This pathway is involved in the regulation of cell growth, differentiation, and survival.

TNF-14 has also been shown to be involved in the regulation of inflammation. It has been shown to promote the production of pro-inflammatory cytokines, such as TNF-伪 and IL-1尾, and to play a role in the regulation of immune cell function.

Another approach to using TNF-14 as a drug target is to target its role in the regulation of cellular processes such as cell adhesion, migration, and survival. TNF-14 has been shown to play a role in the regulation of these processes, and it is thought to be involved in the development of cancer cell migration and the regulation of cell invasion.

In addition to its potential as a drug target, TNF-14 may also be used as a biomarker for cancer. The expression of TNF-14 has been shown to be associated with the development of a variety of cancers, including breast, ovarian, and colorectal cancers. This suggests that TNF-14 may be a useful biomarker for these cancers.

Overall, TNF-14 is a protein that has the potential to be a drug target or biomarker for a variety of cancer types. Further research is needed to fully understand its role in cell signaling and inflammation, as well as its potential as a drug target or biomarker.

Protein Name: TNF Superfamily Member 14

Functions: Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Acts as a ligand for TNFRSF14/HVEM (PubMed:9462508, PubMed:10754304). Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production (PubMed:10754304)

The "TNFSF14 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TNFSF14 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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