BANF1: A Potential Drug Target and Biomarker for Diseases (G8815)

Target Name: BANF1

NCBI ID: G8815

BANF1

BANF1: A Potential Drug Target and Biomarker for Diseases

BANF1 (BANF1 variant 1) is a gene that encodes a protein known as BANF1. BANF1 is a member of the BANF1 family, which is characterized by the presence of a unique N-terminal hypervariable region (HVR) in its amino acid sequence. BANF1 is expressed in a variety of tissues and cells, including brain, heart, and blood vessels.

The BANF1 protein is involved in the regulation of cell adhesion and signaling pathways. It is a key regulator of the cadherin-cathepsin complex, which is responsible for cell-cell adhesion and helps to maintain tissue structure and integrity. In addition to its role in cell adhesion, BANF1 is also involved in the regulation of angiogenesis, the formation of new blood vessels, and the regulation of inflammation.

BANF1 is also a potential drug target for several diseases. Its involvement in cell adhesion and signaling pathways makes it a promising target for therapies that target these pathways. For example, some studies have suggested that BANF1 may be a potential therapeutic target for diseases such as cancer, neurodegenerative diseases, and autoimmune disorders.

In addition to its potential therapeutic applications, BANF1 is also a valuable biomarker for several diseases. Its expression is often reduced in diseases such as cancer, neurodegenerative diseases, and autoimmune disorders, which makes it a potential diagnostic biomarker. In addition, its expression is also often increased in diseases that are characterized by inflammation, such as rheumatoid arthritis and inflammatory bowel disease.

Overall, BANF1 is a protein that is involved in a variety of important biological processes. Its regulation of cell adhesion and signaling pathways makes it a potential target for therapies, and its potential as a biomarker for diseases makes it an important tool for the diagnosis and treatment of these conditions. Further research is needed to fully understand the role of BANF1 in these processes and to develop effective therapies.

Protein Name: BAF Nuclear Assembly Factor 1

Functions: Non-specific DNA-binding protein that plays key roles in mitotic nuclear reassembly, chromatin organization, DNA damage response, gene expression and intrinsic immunity against foreign DNA (PubMed:10908652, PubMed:11792822, PubMed:12163470, PubMed:18005698, PubMed:25991860, PubMed:28841419, PubMed:31796734, PubMed:32792394). Contains two non-specific double-stranded DNA (dsDNA)-binding sites which promote DNA cross-bridging (PubMed:9465049). Plays a key role in nuclear membrane reformation at the end of mitosis by driving formation of a single nucleus in a spindle-independent manner (PubMed:28841419). Transiently cross-bridges anaphase chromosomes via its ability to bridge distant DNA sites, leading to the formation of a dense chromatin network at the chromosome ensemble surface that limits membranes to the surface (PubMed:28841419). Also acts as a negative regulator of innate immune activation by restricting CGAS activity toward self-DNA upon acute loss of nuclear membrane integrity (PubMed:32792394). Outcompetes CGAS for DNA-binding, thereby preventing CGAS activation and subsequent damaging autoinflammatory responses (PubMed:32792394). Also involved in DNA damage response: interacts with PARP1 in response to oxidative stress, thereby inhibiting the ADP-ribosyltransferase activity of PARP1 (PubMed:31796734). Involved in the recognition of exogenous dsDNA in the cytosol: associates with exogenous dsDNA immediately after its appearance in the cytosol at endosome breakdown and is required to avoid autophagy (PubMed:25991860). In case of poxvirus infection, has an antiviral activity by blocking viral DNA replication (PubMed:18005698)

The "BANF1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about BANF1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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