BRK1: A Protein Target for Cancer and Other Diseases (G55845)

Target Name: BRK1

NCBI ID: G55845

BRK1

BRK1: A Protein Target for Cancer and Other Diseases

BRK1 (Protein BRICK1) is a protein that is expressed in various tissues throughout the body, including the brain, heart, liver, and muscle. It is a key regulator of cell signaling pathways, and its dysfunction has been implicated in a number of diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases.

BRK1 has been identified as a potential drug target due to its involvement in several key signaling pathways that are disrupted in many diseases. One of the most significant functions of BRK1 is its role in the PI3K/Akt signaling pathway, which is involved in the regulation of cell proliferation, survival, and angiogenesis. This pathway is often disrupted in cancer cells, and inhibition of BRK1 has been shown to be effective in inhibiting cancer cell growth.

BRK1 is also involved in the regulation of the NF-kappa-B signaling pathway, which is involved in the regulation of inflammation and immune responses. The NF-kappa-B signaling pathway is often disrupted in autoimmune diseases, and inhibition of BRK1 has been shown to be effective in reducing the expression of genes involved in inflammation and immune responses.

In addition to its involvement in the PI3K/Akt and NF-kappa-B signaling pathways, BRK1 is also involved in the regulation of the TGF-β signaling pathway, which is involved in cell growth, differentiation, and survival. The TGF-β signaling pathway is often disrupted in diseases such as cancer, and inhibition of BRK1 has been shown to be effective in inhibiting cancer cell growth and migration.

BRK1 has also been shown to be involved in the regulation of the mitochondrial function, which is important for the regulation of energy metabolism and cell survival. Inherited mutations in the mitochondrial genome have been linked to a number of diseases, including cancer, and inhibition of BRK1 has been shown to be effective in reducing the expression of genes involved in mitochondrial function.

In conclusion, BRK1 is a protein that is involved in the regulation of several key signaling pathways that are disrupted in many diseases. Its dysfunction has been implicated in a number of diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. As a potential drug target, BRK1 has the potential to be used to treat a wide range of diseases.

Protein Name: BRICK1 Subunit Of SCAR/WAVE Actin Nucleating Complex

Functions: Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity)

The "BRK1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about BRK1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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